Hyaluronan molecular weight distribution is associated with the risk of knee osteoarthritis progression
| Autor: | Raj Karia, E.A. Balazs, Philip A. Band, V. Liublinska, Virginia B. Kraus, J. Heeter, Thomas Stabler, Hans-Georg Wisniewski, C.W. Pattanayak |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Male
Risk musculoskeletal diseases medicine.medical_specialty Joint space narrowing Urology Total knee arthroplasty Biomedical Engineering Osteoarthritis Logistic regression Article 03 medical and health sciences 0302 clinical medicine Rheumatology Synovial Fluid Medicine Synovial fluid Humans Orthopedics and Sports Medicine Hyaluronic Acid Hyaluronan 030304 developmental biology Aged 030203 arthritis & rheumatology 0303 health sciences business.industry Disease progression Odds ratio Osteoarthritis progression Middle Aged Osteoarthritis Knee medicine.disease musculoskeletal system Surgery Molecular Weight Knee pain Disease Progression Female medicine.symptom business |
| Zdroj: | Osteoarthritis and Cartilage. 23(1):70-76 |
| ISSN: | 1063-4584 |
| DOI: | 10.1016/j.joca.2014.09.017 |
| Popis: | Summary Objective We investigated the relationship between the molecular weight (MW) distribution of hyaluronan (HA) in synovial fluid (SF) and risk of knee osteoarthritis (OA) progression. Methods HA MW was analyzed for 65 baseline knee SFs. At 3-year follow-up, knees were scored for change in joint space narrowing (JSN), osteophyte (OST) progression, or occurrence of total knee arthroplasty (TKA). HA MW distribution was analyzed using agarose gel electrophoresis (AGE), and its relationship to OA progression was evaluated using logistic regression. The association between HA MW and self-reported baseline knee pain was analyzed using Pearson's correlation coefficients. Results Knee OA was categorized as non-progressing (OST−/JSN−, 26 knees, 40%), or progressing based on OST (OST+/JSN−, 24 knees, 37%), OST and JSN (OST+/JSN+, 7 knees, 11%) or total knee arthroplasty (TKA, 8 knees, 12%). The MW distribution of HA in baseline SFs was significantly associated with the odds of OA progression, particularly for index knees. After adjusting for age, gender, BMI, baseline X-ray grade and pain, each increase of one percentage point in %HA below 1 million significantly increased the odds of JSN (odds ratios (OR) = 1.45, 95% CI 1.02–2.07), TKA or JSN (OR = 1.24, 95%CI 1.01–1.53) and the odds of any progression (OR = 1.16, 95% CI 1.01–1.32). HA MW distribution significantly correlated with pain. Conclusion These data suggest that the odds of knee OA progression increases as HA MW distribution shifts lower and highlight the value of reporting MW distribution rather than just average MW values for HA. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect