High mobility group box 1 and tumor growth factor β: useful biomarkers in pediatric patients receiving peritoneal dialysis

Autor: C Fede, Roberto Chimenz, Valeria Chirico, Michele Buemi, Carmelo Fede, Laura Colavita, Antonio Lacquaniti
Rok vydání: 2016
Předmět:
Male
medicine.medical_specialty
Adolescent
medicine.medical_treatment
030232 urology & nephrology
Peritonitis
Peritoneal equilibration test
030204 cardiovascular system & hematology
Critical Care and Intensive Care Medicine
HMGB1
Gastroenterology
Peritoneal dialysis
03 medical and health sciences
0302 clinical medicine
Peritoneum
Transforming Growth Factor beta
White blood cell
Internal medicine
medicine
Humans
HMGB1 Protein
Child
biology
business.industry
HMGB1
pediatric nephrology
peritoneal biomarkers
peritoneal dialysis adequacy
peritonitis
TGF-β
Critical Care and Intensive Care Medicine
Nephrology
General Medicine
medicine.disease
Prognosis
Surgery
medicine.anatomical_structure
Nephrology
Child
Preschool
Ambulatory
biology.protein
Disease Progression
Kidney Failure
Chronic
Female
business
Peritoneal Dialysis
Biomarkers
Transforming growth factor
Zdroj: Renal failure. 38(9)
ISSN: 1525-6049
Popis: Peritonitis, the most important limitation of peritoneal dialysis (PD), could be detected by biomarkers in dialysate effluent, representing a noninvasive method to indirectly assess the peritoneum status. The aim of our study was to test high mobility group box 1 (HMGB1) in PD patients, evaluating its role as precocious marker of peritoneum damage during peritonitis. Transforming growth factor (TGF)-β was correlated with peritoneal transport characteristics.Six patients, treated by ambulatory PD, were enrolled. Samples were collected at the onset of peritonitis (T1) and every day until its resolution (T-end). Serum (s) and peritoneal (p) white blood cell (WBC) count was also evaluated. Peritoneal Equilibration Test evaluated the filter activity of peritoneum.In patients with acute peritonitis, the highest serum and peritoneal HMGB1 values (64 ± 3.6 and 70 ± 5.3 ng/mL, respectively) were assessed, with a progressive decrease of their levels at the resolution time (T-end: sHMGB1:36 ± 2.5; pHMGB1:30.5 ± 7.0 ng/mL). While no differences of sWBC and pWBC were observed between baseline and T-end values, pHMGB1 levels remained higher at T-end than those observed at T0 (pHMGB1:30.5 ± 7.0 versus 6.9 ± 3.6; p 0.0001). TGF-β levels were higher in patients with low peritoneal permeability than in medium or high transporter patients (81 ± 15.5 versus 24.3 ± 7.5 pg/mL; p = 0.01). An inverse correlation was found between TGF-β levels and dialysate/plasmatic creatinine values (r = -0.83; p = 0.03).HMGB1 represents a useful biomarker for peritoneum evaluation in PD patients. A prognostic role of this alarmin, as a marker of response to therapy, could be hypothesized. TGF-β could predict the peritoneal transport status and dialysis technique adequacy.
Databáze: OpenAIRE
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