Peripheral neuropathy in systemic lupus erythematosus: what can neuromuscular ultrasonography (NMUS) tell us? A cross-sectional study
| Autor: | Tayseer M. Khedr, Marco Matucci-Cerinic, Doaa M. M. Osman, Safaa A Mahran, Serena Guiducci, Alvaro Garcia Martos, Felice Galluccio, Amira M Elsonbaty, Marwa A.A. Galal, Abdallah El Sayed Allam |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male medicine.medical_specialty Popliteal fossa Immunology Urology 03 medical and health sciences Young Adult 0302 clinical medicine systemic lupus erythematosus medicine Clinical Trials and Drug Discovery Humans Lupus Erythematosus Systemic autoimmune diseases Tarsal tunnel Tibial nerve Ulnar nerve Ulnar Nerve 030203 arthritis & rheumatology medicine.diagnostic_test business.industry Peripheral Nervous System Diseases General Medicine ultrasonography RC581-607 medicine.disease medicine.anatomical_structure Peripheral neuropathy Cross-Sectional Studies Nerve conduction study Histopathology Female Immunologic diseases. Allergy business Polyneuropathy 030217 neurology & neurosurgery |
| Zdroj: | Lupus Science & Medicine Lupus Science and Medicine, Vol 8, Iss 1 (2021) |
| ISSN: | 2053-8790 |
| Popis: | ObjectiveTo evaluate peripheral nerve involvement in patients with SLE with neuromuscular ultrasonography (NMUS) and understand its role in investigating SLE-related peripheral neuropathy.MethodsThis is an observational cross-sectional study on patients with SLE and healthy controls. Five nerves in each patient were examined bilaterally with NMUS, and the cross-sectional area (CSA) of each nerve at certain sites was estimated. The mean CSA at each site, for each nerve, in each group was statistically analysed and compared between groups.Results370 nerves were evaluated in 37 patients. By nerve conduction study (NCS), 36 patients had polyneuropathy (80.6% mixed type, 19.4% sensory). Significant mean CSA enlargement was present among the ulnar nerve at the Guyon’s canal and mid-humerus (both p=0.001); tibial nerve at the distal leg and proximal to the tarsal tunnel (p=0.003 and p=0.001, respectively); and peroneal nerve at the popliteal fossa (p=0.042). The mean CSA showed high specificity compared with NCS.ConclusionOur study shows that CSA could be a complementary tool to NCS for studying peripheral neuropathy in SLE. Furthermore, NMUS provides data on the different pathophysiological aspects of nerve involvement in SLE. Future studies using more than one sonographic parameter in combination with NCS and nerve histopathology are recommended to further investigate SLE-related neuropathy.Trial registration numberNCT04527172. |
| Databáze: | OpenAIRE |
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