Social and emotional processing in Prader-Willi syndrome: genetic subtype differences
| Autor: | Elisabeth M. Dykens, Dorita Jones, Alexandra P. Key |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Event-related potential
medicine.medical_specialty Neurology Face perception Cognitive Neuroscience Emotion processing Emotional processing Stimulus (physiology) 050105 experimental psychology Pathology and Forensic Medicine Developmental psychology 03 medical and health sciences 0302 clinical medicine medicine Attention 0501 psychology and cognitive sciences Oddball paradigm Research 05 social sciences Neuropsychology medicine.disease Autism spectrum disorder Pediatrics Perinatology and Child Health Neurology (clinical) Prader-Willi syndrome Psychology 030217 neurology & neurosurgery |
| Zdroj: | Journal of Neurodevelopmental Disorders |
| ISSN: | 1866-1955 1866-1947 |
| DOI: | 10.1186/1866-1955-5-7 |
| Popis: | Background People with Prader-Willi syndrome (PWS) demonstrate social dysfunction and increased risk of autism spectrum disorder, especially those with the maternal uniparental disomy (mUPD) versus paternal deletion genetic subtype. This study compared the neural processing of social (faces) and nonsocial stimuli, varying in emotional valence, across genetic subtypes in 24 adolescents and adults with PWS. Methods Upright and inverted faces, and nonsocial objects with positive and negative emotional valence were presented to participants with PWS in an oddball paradigm with smiling faces serving as targets. Behavioral and event-related potential (ERP) data were recorded. Results There were no genetic subtype group differences in accuracy, and all participants performed above chance level. ERP responses revealed genetic subtype differences in face versus object processing. In those with deletions, the face-specific posterior N170 response varied in size for face stimuli versus inverted faces versus nonsocial objects. Persons with mUPD generated N170 of smaller amplitude and showed no stimulus differentiation. Brain responses to emotional content did not vary by subtype. All participants elicited larger posterior and anterior late positive potential responses to positive objects than to negative objects. Emotion-related differences in response to faces were limited to inverted faces only in the form of larger anterior late positive potential amplitudes to negative emotions over the right hemisphere. Detection of the target smiling faces was evident in the increased amplitude of the frontal and central P3 responses but only for inverted smiling faces. Conclusion Persons with the mUPD subtype of PWS may show atypical face versus object processes, yet both subtypes demonstrated potentially altered processing, attention to and/or recognition of faces and their expressions. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink