Relationship between epidermal growth factor and its receptor in human benign prostatic hyperplasia
| Autor: | Carla Lubrano, N. Rombola, E. Petrangeli, F. Sciarra, Vincenzo Toscano, M.C. Trotta, F. Di Silverio, Giovanni Spera, Luigi Frati |
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| Rok vydání: | 1993 |
| Předmět: |
Male
medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment Clinical Biochemistry Prostatic Hyperplasia Biochemistry Paracrine signalling Endocrinology Prostate Epidermal growth factor Internal medicine medicine Humans Binding site Receptor Autocrine signalling Molecular Biology Aged Immunoassay Epidermal Growth Factor business.industry Growth factor Cell Membrane Cell Biology Middle Aged Hyperplasia medicine.disease ErbB Receptors medicine.anatomical_structure Molecular Medicine business |
| Zdroj: | The Journal of Steroid Biochemistry and Molecular Biology. 46:463-468 |
| ISSN: | 0960-0760 |
| DOI: | 10.1016/0960-0760(93)90100-b |
| Popis: | Human benign prostatic hyperplasia (BPH) samples were analyzed to evaluate the presence of immunoreactive epidermal growth factor (irEGF) and EGF receptor (EGFR). In all BPH samples examined both peptide and its receptor were present. Scatchard analysis of binding data of [125I]EGF showed two classes of binding sites with high and low affinity. Intratissular irEGF concentrations showed a significant inverse linear correlation with EGFR levels. Two groups of samples can be identified: the first showing high irEGF concentrations and low levels of EGF binding sites; the second low irEGF and high concentrations of EGFR. The simultaneous presence of EGF and its receptor in BPH samples indicates that this growth factor may act in an autocrine/paracrine manner in human prostatic tissue. The inverse relationship between EGF and the two sites of EGFR lead one to hypothesize that EGF itself could play a central role in determining receptor cell surface availability. |
| Databáze: | OpenAIRE |
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