Thalamic calcification in vitamin D receptor knockout mice
| Autor: | Allan V. Kalueff, Tiina Keisala, Susanna Miettinen, Hannu Haapasalo, Anna Minasyan, Pentii Tuchimaa, Marianne Kuuslahti, Immo Rantala, Jaakko Keranen, Elena Loseva, Yan-Ru Lou |
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| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Biology Calcitriol receptor vitamin D deficiency Mice Thalamus Internal medicine medicine Vitamin D and neurology Animals Receptor Mice Knockout General Neuroscience Age Factors Calcinosis Spectrometry X-Ray Emission Phosphorus Vitamin D Deficiency medicine.disease Steroid hormone Endocrinology Knockout mouse Receptors Calcitriol Thalamic calcification Calcium Calcification |
| Zdroj: | University of Helsinki |
| Popis: | Vitamin D is a steroid hormone with many important functions in the brain, mediated through the nuclear vitamin D receptor. Here, we report that aging nuclear vitamin D receptor knockout mice demonstrate a symmetric thalamic calcification with numerous Ca/P-containing laminated bodies. These results are consistent with clinical findings showing brain calcification in patients with vitamin D deficiency. Our results suggest that nuclear vitamin D receptor deficiency leads to brain mineralization in vitamin D receptor knockout mice, which may represent an experimental model of intracranial calcification. |
| Databáze: | OpenAIRE |
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