Correlates and outcomes of alcohol use after single solid organ transplantation: A systematic review and meta-analysis

Autor: Dobbels, F, Denhaerynck, K, Klem, Ml, Sereika, Sm, De Geest, S, De Simone, P, B-SERIOUS, Consortium, Berben, L, Binet, I, Burkhalter, H, Drent, G, Duerinckx, N, Engberg, Sj, Glass, T, Gordon, E, Kirsch, M, Kugler, C, Lerret, S, Rossmeissl, A, Russell, C, Schmidt-Trucksäss, A, de Almeida SS
Rok vydání: 2019
Předmět:
medicine.medical_specialty
Alcohol Drinking
Post-transplant outcome
medicine.medical_treatment
Immunology
Alcohol
030230 surgery
Liver transplantation
Odds
RETROSPECTIVE ANALYSIS
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Sobriety
Solid organ transplantation
Quality of life
Internal medicine
Humans
Medicine
SUBSTANCE-ABUSE
TERM-FOLLOW-UP
CARBOHYDRATE-DEFICIENT TRANSFERRIN
Transplantation
Science & Technology
business.industry
ABSTINENCE RULE
TOBACCO USE
Organ Transplantation
Odds ratio
GLOBAL BURDEN
Transplant Recipients
Meta-analysis
Risk factors
chemistry
ORTHOTOPIC LIVER-TRANSPLANTATION
Sample size determination
Systematic review
RISK-FACTORS
Quality of Life
030211 gastroenterology & hepatology
RELAPSE SCALE
Alcohol use
business
Life Sciences & Biomedicine
Zdroj: Transplantation Reviews. 33:17-28
ISSN: 0955-470X
Popis: BACKGROUND: Reviews on alcohol use in transplant recipients focus on liver recipients and their risk of post-transplant rejection, but do not assess alcohol use in kidney, heart, or lung transplant recipients. This systematic review and meta-analysis aims to synthesize the evidence on correlates and outcomes of any alcohol use and at-risk drinking after solid organ transplantation (Tx). METHODS: We searched 4 databases for quantitative studies in adult heart, liver, kidney and lung Tx recipients, investigating associations between post-Tx alcohol use and correlates and/or clinical, economic or quality of life outcomes. Paper selection, data extraction and quality assessment were performed by 2 reviewers independently. A pooled odds ratio (OR) was computed for each correlate/outcome reported ≥5 times. RESULTS: Of the 5331 studies identified, 76 were included in this systematic review (93.3% on liver Tx; mean sample size 148.9 (SD = 160.2); 71.9% male; mean age 48.9 years (SD = 6.5); mean time post-Tx 57.7 months (SD = 23.1)). On average, 23.6% of patients studied used alcohol post-transplant. Ninety-three correlates of any post-Tx alcohol use were identified, and 9 of the 19 pooled ORs were significantly associated with a higher odds for any post-Tx alcohol use: male gender, being employed post-transplant, smoking pre-transplant, smoking post-transplant, a history of illicit drug use, having first-degree relatives who have alcohol-related problems, sobriety
Databáze: OpenAIRE
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