The antioxidant anethole dithiolethione inhibits monoamine oxidase-B but not monoamine oxidase A activity in extracts of cultured astrocytes
| Autor: | C. A. M. Jongenelen, Jeffrey S. Flier, Benjamin Drukarch, Gerda Andringa, A. N. M. Schoffelmeer |
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| Přispěvatelé: | Anatomy and neurosciences |
| Rok vydání: | 2005 |
| Předmět: |
Clorgyline
Monoamine Oxidase Inhibitors Antioxidant Anethole Trithione Monoamine oxidase medicine.medical_treatment Pharmacology medicine.disease_cause Neuroprotection Antioxidants Basal Ganglia chemistry.chemical_compound medicine Animals Monoamine Oxidase Cells Cultured Biological Psychiatry Anethole Analysis of Variance Dose-Response Relationship Drug biology Rats Enzyme Activation Psychiatry and Mental health Animals Newborn Neurology chemistry Astrocytes biology.protein Anethole trithione Neurology (clinical) Monoamine oxidase B Monoamine oxidase A Oxidative stress medicine.drug |
| Zdroj: | Journal of Neural Transmission, 113(5), 593-8. Springer Verlag Drukarch, B, Flier, J, Jongenelen, C A M, Andringa, G & Schoffelmeer, A N M 2006, ' The antioxidant anethole dithiolethione inhibits monoamine oxidase-B but not monoamine oxidase A activity in extracts of cultured astrocytes ', Journal of Neural Transmission, vol. 113, no. 5, pp. 593-8 . https://doi.org/10.1007/s00702-005-0350-0 |
| ISSN: | 1435-1463 0300-9564 |
| Popis: | Anethole dithiolethione (ADT) is a clinically available, pluripotent antioxidant proposed as a neuroprotectant for Parkinson's disease (PD). Here, using extracts from cultured astrocytes, containing both monoamine oxidase (MAO) A and B activity, we demonstrate that ADT concentration-dependently inhibits MAO-B activity in a clinically relevant concentration range (0.03-30 microM, IC-50 = 0.5 microM) without affecting MAO A activity. Considering the alleged contribution of MAO activity in general, and MAO-B in particular, to oxidative stress and neurodegeneration in PD, our data further support the neuroprotective potential of ADT. |
| Databáze: | OpenAIRE |
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