Cardiotoxic and Dyslipidemic Effects of Doxorubicin and Betulinic Acid Amide
| Autor: | T. G. Tolstikova, E. L. Lushnikova, E. V. Koldysheva, I. V. Sorokina, M. G. Klinnikova, M. M. Mzhelskaya, E. I. Yuzhik |
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| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine Blood lipids Connective tissue Pharmacology General Biochemistry Genetics and Molecular Biology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Malondialdehyde Amide Betulinic acid medicine Animals Myocytes Cardiac Doxorubicin Rats Wistar Betulinic Acid Triglycerides Cell Size Dyslipidemias Antibiotics Antineoplastic Triglyceride Cholesterol Myocardium Body Weight Cholesterol HDL Cholesterol LDL Organ Size General Medicine Catalase Amides Antineoplastic Agents Phytogenic Cardiotoxicity Triterpenes Rats Drug Combinations 030104 developmental biology medicine.anatomical_structure chemistry Rat myocardium Pentacyclic Triterpenes 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 162:277-282 |
| ISSN: | 1573-8221 0007-4888 |
| Popis: | Changes in the blood lipid spectrum and structural reorganization of the rat myocardium in response to injection of a single sublethal dose of doxorubicin (7 mg/kg) alone and in combination with course administration of betulonic acid amide (100 mg/kg/day for 14 days) were studied. Betulinic acid amide in the specified dose exhibited less pronounced cardiotoxic (necrobiotic impairment of cardiomyocytes) and dyslipidemic (increase of cholesterol and triglyceride levels) effects in comparison with doxorubicin. Combined treatment with betulinic acid amide and doxorubicin led to more pronounced remodeling of the myocardium, which was shown by a significant increase of the connective tissue/cardiomyocyte volume ratio detected by day 14 of the experiment. |
| Databáze: | OpenAIRE |
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