Subcutaneous phaeohyphomycosis due to Exophiala jeanselmei following renal transplantation: A case report with a published work review of phaeohyphomycosis in Japan
| Autor: | Katsutaro Nishimoto, Motoi Takenaka, Hiroyuki Murota |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
medicine.medical_specialty Itraconazole Dermatology Lesion 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Japan Exophiala medicine Humans Abscess Immunodeficiency Aged medicine.diagnostic_test biology business.industry Exophiala jeanselmei General Medicine medicine.disease biology.organism_classification Kidney Transplantation Transplantation Phaeohyphomycosis 030220 oncology & carcinogenesis Skin biopsy Female medicine.symptom business medicine.drug |
| Zdroj: | The Journal of Dermatology. 47:1050-1053 |
| ISSN: | 1346-8138 0385-2407 |
| Popis: | We describe a case of cutaneous phaeohyphomycosis following renal transplantation and include a review of the previously published Japanese cases. A 40-year-old Japanese woman taking immunosuppressants following renal transplantation 6 years prior presented to our hospital with a subcutaneous lesion on her right leg. Skin biopsy revealed an abscess, and culture confirmed Exophiala jeanselmei to be the causative agent. Treatment with itraconazole combined with surgical drainage was effective, and the lesion disappeared after 15 months. Upon review of 128 Japanese phaeohyphomycosis cases, it was found that more than 80% of the cases occurred in patients aged more than 60 years, and most cases involved underlying diseases associated with immunodeficiency. E. jeanselmei was the most common etiologic fungus. Recently, however, the Exophiala species has been reclassified based on molecular identification, and cases due to E. jeanselmei decreased with the concomitant increase of cases due to Exophiala oligosperma and Exophiala xenobiotica. In approximately half of the cases, lesions were treated by surgical removal, with or without concomitant antifungal drugs. Itraconazole was the antifungal agent most frequently used. In many cases, the disease course was reported as either healing or improving. There was no difference in either treatment or prognosis based on the etiologic species of fungus. |
| Databáze: | OpenAIRE |
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