A time to revisit the two oldest prandial anti-diabetes agents: acarbose and repaglinide
| Autor: | Reza Pishdad, Parisa Pishdad, Yunes Panahi, Gholam Reza Pishdad |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Blood Glucose
medicine.medical_specialty Endocrinology Diabetes and Metabolism 030209 endocrinology & metabolism Type 2 diabetes Hypoglycemia Gastroenterology 03 medical and health sciences 0302 clinical medicine Endocrinology Piperidines Internal medicine Diabetes mellitus medicine Humans Hypoglycemic Agents Insulin Prospective Studies Acarbose Glycated Hemoglobin Insulin glargine business.industry medicine.disease Repaglinide Metformin Postprandial Diabetes Mellitus Type 2 030220 oncology & carcinogenesis Carbamates business medicine.drug |
| Zdroj: | Endocrine. 70:307-313 |
| ISSN: | 1559-0100 1355-008X |
| DOI: | 10.1007/s12020-020-02396-0 |
| Popis: | Compared with newer prandial anti-diabetes agents, repaglinide and acarbose are unique in being globally available in generic versions, being oral, and being the cheapest of all. The aim of this study was to compare their efficacy when used alone or in combination.In a randomized, double-blind, prospective study, 358 recently diagnosed type 2 diabetes (T2D) patients, who on a combined therapy with metformin and insulin glargine had a fasting plasma glucose (FGP) of7.2 mmol/L but a 2-h postprandial plasma glucose (2hPPG)10 mmol/L, were assigned to three groups of additional treatment with either repaglinide, acarbose, or repaglinide-plus-acarbose for 4 months.With intention-to-treat analysis, 63% of repaglinide group, 45.4 percent of acarbose group, and 75.7% of repaglinide-plus-acarbose group reached the primary endpoint of 2hPPG 10 mmol/L while maintaining FPG 7.2 mmol/L. Treatment adherence rate was 75.6% with repaglinide, 61.4% with acarbose, and 81.3% with repaglinide-plus-acarbose (p = 0.001). Among the groups, weight was significantly lower in acarbose group (p 0.05). Twenty-one percent of repaglinide patients, 4.9% of acarbose subjects, and 10.3% of repaglinide-plus-acarbose cases reported at least one episode of hypoglycemia (p 0.005). HbA1C and basal insulin requirement were significantly lower in repaglinide group (p = 0.004, p = 0.0002). Triglycerides were lowest in acarbose group (p = 0.005).Both acarbose and repaglinide were vastly effective in lowering postprandial hyperglycemia of recently diagnosed T2D. When combined, they were even more efficacious and the disease had a better outcome. Compared with newer peers, these two are particularly useful where and when cost consideration in diabetes treatment is a prime concern. |
| Databáze: | OpenAIRE |
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