The Effectiveness of Endoscopic Gastroplasty for Obesity Treatment According to FDA Thresholds: Systematic Review and Meta-Analysis Based on Randomized Controlled Trials
| Autor: | Vitor Ottoboni Brunaldi, Iatagan Josino, Eduardo Turiani Hourneaux de Moura, Rafael K. Martins, Diogo Turiani Hourneaux de Moura, Wanderley Marques Bernardo, Marco Aurelio Santo, Thiago Ferreira de Souza, Antonio Coutinho Madruga-Neto, Eduardo Guimarães Hourneaux de Moura |
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| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Gastroplasty Endocrinology Diabetes and Metabolism MEDLINE law.invention 03 medical and health sciences 0302 clinical medicine Randomized controlled trial law Weight loss Internal medicine Weight Loss medicine Humans Obesity 030212 general & internal medicine Randomized Controlled Trials as Topic Nutrition and Dietetics medicine.diagnostic_test business.industry Endoscopy Total body medicine.disease LAPAROSCOPIA Conservative treatment Meta-analysis 030211 gastroenterology & hepatology Surgery medicine.symptom business |
| Zdroj: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| ISSN: | 1708-0428 0960-8923 |
| DOI: | 10.1007/s11695-018-3335-4 |
| Popis: | Endoscopic bariatric therapies (EBTs) are promising alternatives to conventional surgery for obesity. The aim of this study is to compare efficacy and safety through a systematic review and meta-analysis of the endoscopic gastroplasty techniques versus conservative treatment. We searched MEDLINE, EMBASE, Cochrane CENTRAL, Lilacs/Bireme. Randomized controlled trials (RCTs) enrolling obese patients comparing endoscopic gastroplasty to sham or diet/exercise were considered eligible. Among 6014 records, three RCTs were selected for meta-analysis. The total sample was 459 patients (312 EBTs vs 147 control). Mean total body weight loss in the intervention group (IG) was 4.8% higher than the control group (CG) at 12 months (p = 0.01). The IG responder rate was 44.31% at 12 months. Therefore, the endoscopic gastroplasty is more effective than conservative therapies but do not achieve FDA thresholds. |
| Databáze: | OpenAIRE |
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