Influence of child abuse on adult depression: moderation by the corticotropin-releasing hormone receptor gene

Autor: Yi-Lang Tang, Charles B. Nemeroff, Michael P. Epstein, Joseph F. Cubells, Mark Evces, Hemu P. Nair, Wei Liu, D. Jeffrey Newport, Charles F. Gillespie, Ann C. Schwartz, Rebekah Bradley, Christine Heim, Kerry J. Ressler, Tiina Berg, Elisabeth B. Binder, Zachary N. Stowe
Rok vydání: 2008
Předmět:
Child abuse
Male
Bipolar Disorder
Personality Inventory
Poison control
Social Environment
Linkage Disequilibrium
Gene Frequency
Risk Factors
Child Abuse
CRHR1 Gene
Child
Aged
80 and over
education.field_of_study
Mental Disorders
Middle Aged
Psychiatry and Mental health
Phenotype
Major depressive disorder
Female
Psychology
Adult
Cross-Cultural Comparison
medicine.medical_specialty
Adolescent
Genotype
Population
Black People
Polymorphism
Single Nucleotide
Receptors
Corticotropin-Releasing Hormone
Article
White People
Arts and Humanities (miscellaneous)
medicine
Humans
Genetic Predisposition to Disease
Bipolar disorder
Allele
education
Psychiatry
Alleles
Probability
Aged
Depressive Disorder
Major
Beck Depression Inventory
medicine.disease
Genetics
Population
Haplotypes
Socioeconomic Factors
Chromosomes
Human
Pair 16
Zdroj: Archives of general psychiatry. 65(2)
ISSN: 1538-3636
Popis: Genetic inheritance and developmental life stress both contribute to major depressive disorder in adults. Child abuse and trauma alter the endogenous stress response, principally corticotropin-releasing hormone and its downstream effectors, suggesting that a gene x environment interaction at this locus may be important in depression.To examine whether the effects of child abuse on adult depressive symptoms are moderated by genetic polymorphisms within the corticotropin-releasing hormone type 1 receptor (CRHR1) gene.Association study examining gene x environment interactions between genetic polymorphisms at the CRHR1 locus and measures of child abuse on adult depressive symptoms.General medical clinics of a large, public, urban hospital and Emory University, Atlanta, Georgia.The primary participant population was 97.4% African American, of low socioeconomic status, and with high rates of lifetime trauma (n = 422). A supportive independent sample (n = 199) was distinct both ethnically (87.7% Caucasian) and socioeconomically (less impoverished).Beck Depression Inventory scores and history of major depressive disorder by the Structured Clinical Interview for DSM-IV Axis I Disorders.Fifteen single-nucleotide polymorphisms spanning 57 kilobases of the CRHR1 gene were examined. We found significant gene x environment interactions with multiple individual single-nucleotide polymorphisms (eg, rs110402, P = .008) as well as with a common haplotype spanning intron 1 (P.001). Specific CRHR1 polymorphisms appeared to moderate the effect of child abuse on the risk for adult depressive symptoms. These protective effects were supported with similar findings in a second independent sample (n = 199).These data support the corticotropin-releasing hormone hypothesis of depression and suggest that a gene x environment interaction is important for the expression of depressive symptoms in adults with CRHR1 risk or protective alleles who have a history of child abuse.
Databáze: OpenAIRE
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