Defining the dose‐volume criteria for laryngeal sparing in locally advanced oropharyngeal cancer utilizing split‐field IMRT, whole‐field IMRT and VMAT
| Autor: | David I. Rosenthal, Jack Phan, Christopher Wilke, Clifton D. Fuller, William H. Morrison, Amy C. Moreno, Sean R. Quinlan-Davidson, Jay Reddy, Adam S. Garden, Gary Brandon Gunn, Congjun Wang, Katherine A. Hutcheson, Shih Ming Samuel Tung, George Zhao, Vinita Takiar, He Wang |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Larynx
Organs at Risk medicine.medical_specialty medicine.medical_treatment Locally advanced VMAT split‐field 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine medicine otorhinolaryngologic diseases Dosimetry Radiation Oncology Physics Humans Radiology Nuclear Medicine and imaging Stage (cooking) Esophagus IMRT Instrumentation Radiation dosimetry business.industry Radiotherapy Planning Computer-Assisted Cancer Radiotherapy Dosage Thyroid cartilage medicine.disease Radiation therapy stomatognathic diseases Oropharyngeal Neoplasms medicine.anatomical_structure 030220 oncology & carcinogenesis Radiology oropharynx Radiotherapy Intensity-Modulated business |
| Zdroj: | Journal of Applied Clinical Medical Physics |
| ISSN: | 1526-9914 |
| Popis: | Purpose To determine the optimal dose‐volume constraint for laryngeal sparing using three commonly employed intensity modulated radiation therapy (IMRT) approaches in patients with oropharyngeal cancer treated to the bilateral neck. Materials and methods Thirty patients with stage II‐IVA oropharynx cancers received definitive radiotherapy with split‐field IMRT (SF‐IMRT) to the bilateral neck between 2008 and 2013. Each case was re‐planned using whole‐field IMRT (WF‐IMRT) and volumetric modulated arc therapy (VMAT) and plan quality metrics and dose to laryngeal structures was evaluated. Two larynx volumes were defined and compared on the current study: the Radiation Therapy Oncology Group (RTOG) larynx as defined per the RTOG 1016 protocol and the MDACC larynx defined as the components of the larynx bounded by the superior and inferior extent of the thyroid cartilage. Results Target coverage, conformity, and heterogeneity indices were similar in all techniques. The RTOG larynx mean dose was lower with WF‐IMRT than SF‐IMRT (22.1 vs 25.8 Gy; P |
| Databáze: | OpenAIRE |
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