Correlation analysis between single nucleotide polymorphisms of pulmonary surfactant protein A gene and pulmonary tuberculosis in the Han population in China
| Autor: | Hui Chen, Xiao-wen Li, Yi-ge Wang, Yu-ling Zhao, Chao-yang Xu, Xiaoguang Ma, Hong-yi Yang, Hui Li |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Microbiology (medical) China Han population Single-nucleotide polymorphism Logistic regression Polymorphism Single Nucleotide lcsh:Infectious and parasitic diseases SFTPA2 Humans SNP Genetic Predisposition to Disease lcsh:RC109-216 Allele Tuberculosis Pulmonary Pulmonary surfactant protein A Gene Alleles Genetics Pulmonary Surfactant-Associated Protein A biology Pulmonary tuberculosis Haplotype Single nucleotide polymorphisms General Medicine Middle Aged Logistic Models Infectious Diseases Haplotypes Case-Control Studies biology.protein Female Protein A |
| Zdroj: | International Journal of Infectious Diseases, Vol 26, Iss C, Pp 31-36 (2014) |
| ISSN: | 1201-9712 |
| Popis: | Objective: To investigate the correlation of single nucleotide polymorphisms (SNPs) in SFTPA1 and SFTPA2 genes encoding pulmonary surfactant protein A (SP-A) with the susceptibility to pulmonary tuberculosis (PTB) in the Han population in China. Methods: This study included 248 patients with active PTB (case group) and 124 normal individuals (control group). SNPs at loci aa19, aa50, aa62, aa133, and aa219 of SFTPA1, and at loci aa9, aa91, aa140, and aa223 of SFTPA2 were analyzed with PCR. Multivariate logistic regression analysis was used to identify the correlation of age, sex, and SNPs with PTB. Results: The frequencies of the G allele at aa91 and T allele at aa140 in SFTPA2 were significantly higher in the case group than in the control group (p = 0.0002 and p = 0.045). The distribution of haplotype CGAAC in SFTPA1 was significantly lower in the case group than in the control group (p = 0.025). In SFTPA2, the distributions of haplotypes 1A6, 1A10, 1A9, and 1A2 were higher (all p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|