Assessments of serum copper and zinc concentration, and the Cu/Zn ratio determination in patients with multidrug resistant pulmonary tuberculosis (MDR-TB) in Côte d’Ivoire
| Autor: | K. N’guessan, Allico Joseph Djaman, Gnogbo Alexis Bahi, Alain Dit Philippe Bidie, Souleymane Meite, Kadjowely Yeo, Gervais Melaine M’boh, Lydie Boyvin |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male Antitubercular Agents medicine.disease_cause Gastroenterology Tuberculosis Multidrug-Resistant Prevalence GeneXpert MTB/RIF Isoniazid Second-line anti-TB drugs Middle Aged Zinc Infectious Diseases Female Rifampin medicine.drug Research Article Adult medicine.medical_specialty Tuberculosis Adolescent Victoria 030106 microbiology Cu/Zn Ratio chemistry.chemical_element MDR-TB lcsh:Infectious and parasitic diseases 03 medical and health sciences Young Adult Internal medicine medicine Humans lcsh:RC109-216 Tuberculosis Pulmonary Trace elements 030109 nutrition & dietetics business.industry Abidjan medicine.disease Copper Multiple drug resistance Oxidative Stress Cote d'Ivoire chemistry Immunology business Oxidative stress Rifampicin |
| Zdroj: | BMC Infectious Diseases BMC Infectious Diseases, Vol 17, Iss 1, Pp 1-6 (2017) |
| ISSN: | 1471-2334 |
| Popis: | Background In Côte d’Ivoire, multidrug-resistant tuberculosis (MDR-TB) is a serious public health problem with a prevalence estimated at 2.5% in 2006. Zinc and copper are essential Trace element needed to strengthen the immune system and also useful in the fight against tuberculosis. The Cu / Zn ratio is a good indicator of oxidative stress. The principal aim of this study was to evaluate the serum concentration of some trace element and determine the Cu / Zn ratio in patients with multidrug resistant pulmonary tuberculosis (MDR-TB) before and after second line treatment of TB. Methods Blood samples were obtained from 100 MDR-TB patients after confirmation of their status through the microscopic and molecular diagnosis of resistance to Isoniazid and Rifampicin by GeneXpert. The concentration level of zinc and copper were determined using flame air / acetylene atomic absorption spectrometer (AAS) Type Varian Spectr AA-20 Victoria, Australlia. Results A significant decrease in zinc levels (P |
| Databáze: | OpenAIRE |
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