Investigation of anti-inflammatory and antinociceptive activities of trans-dehydrocrotonin, a 19-nor-clerodane diterpene from Croton cajucara. Part 1

Autor:	Angelo C. Pinto, S J Sarti, Maria Aparecida Medeiros Maciel, Domingos Sávio Nunes, Ronaldo Mendes Lima, José Carlos Tavares Carvalho, Maria Fernanda Coser Silva, Jairo Kenupp Bastos
Rok vydání:	1996
Předmět:	Male medicine.drug_class Pharmaceutical Science Pain Median lethal dose Anti-inflammatory Analytical Chemistry Diterpenes Clerodane Lethal Dose 50 chemistry.chemical_compound Acetic acid Mice Drug Discovery Clerodane diterpene Medicine Animals Rats Wistar Pharmacology Analgesics Granuloma Plants Medicinal Traditional medicine biology Morphine business.industry Organic Chemistry Anti-Inflammatory Agents Non-Steroidal Euphorbiaceae Biological activity biology.organism_classification Rats Complementary and alternative medicine chemistry visual_art visual_art.visual_art_medium Molecular Medicine Bark Diterpene Diterpenes business Brazil
Zdroj:	Planta medica. 62(5)
ISSN:	0032-0943
Popis:	The anti-inflammatory and antinociceptive effects of trans-dehydrocrotonin, isolated from the bark of Croton cajucara (Euphorbiaceae), were investigated using several animal models. The trans-dehydrocrotonin produced a significant inhibition of carrageenin-induced paw edema and cotton pellet granuloma in rats. It also inhibited the writhings in mice induced by acetic acid, but did not show a significant effect in the hot-plate test in mice. The LD50 of t-DCTN was 555.0 mg/kg (p.o.) for mice.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be203f937df246f8787a7e4e4f3ac30a https://pubmed.ncbi.nlm.nih.gov/8923802 Zobrazit plný text záznamu