Toxic Effects of Violamycin BI, Carminomycin and Daunorubicin on the Myocardium of Rabbits
| Autor: | E. Kirchner, Härtl A, Güttner J, Hoffmann H, R S Fritsch |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Male
Anthracycline Daunorubicin medicine.drug_class Hydrothorax Antibiotics Pharmacology Toxicology Lesion Ascites medicine Animals Cardiotoxicity Dose-Response Relationship Drug business.industry Carubicin Myocardium Cardiac muscle Heart Anti-Bacterial Agents Dose–response relationship Aminoglycosides medicine.anatomical_structure Female Rabbits medicine.symptom business Pericardium medicine.drug |
| Zdroj: | Acta Pharmacologica et Toxicologica. 48:87-94 |
| ISSN: | 0001-6683 |
| DOI: | 10.1111/j.1600-0773.1981.tb01593.x |
| Popis: | Cardiac toxicity of the new anthracycline antitumour antibiotics violamycin BI (V) and carminomycin (C) was studied in comparison with daunorubicin (D). Rabbits were intravenously given total doses of 0.1-1.5 mg/kg V or C, and 0.64-18 mg/kg D, respectively, twice weekly for one month. When examined two to six days, two and four weeks, respectively, after the last drug administration the gross findings consisted of hydropericard, hydrothorax and ascites in some animals. Histologically, loss of striation and focal necrosis of cardiac muscle cells and subsequently chronic inflammatory reactions and/or proliferation of mesenchyma cells were mostly found. These alterations were somewhat more pronounced in rabbits treated with V than in animals received D or C. At equitoxic doses of the antibiotics tested the ultrastructural lesion in the myocardial cells were altogether less marked after treatment with D than with C or V. |
| Databáze: | OpenAIRE |
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