Lung Transplantation at the University of Lund 1990-1995: Analysis of the First 39 Consecutive Patients
| Autor: | Stig Steen, Lena Mared, Leif Eriksson, Bansi Koul, Jan Otto Solem |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Adult
Lung Diseases Male medicine.medical_specialty Adolescent medicine.medical_treatment Work Capacity Evaluation Bronchiolitis obliterans Hospitals University Postoperative Complications Predictive Value of Tests Epidemiology Humans Medicine Lung transplantation Child Bronchiolitis Obliterans Survival analysis Retrospective Studies Sweden Lung business.industry Syndrome Middle Aged University hospital medicine.disease Respiratory Function Tests Surgery Survival Rate Transplantation medicine.anatomical_structure Child Preschool Female Cardiology and Cardiovascular Medicine business Complication Follow-Up Studies Lung Transplantation |
| Zdroj: | Scandinavian Cardiovascular Journal. 32:23-28 |
| ISSN: | 1651-2006 1401-7431 |
| Popis: | Between 1990 and 1995 39 patients were lung transplanted at the University Hospital in Lund. This is a retrospective review of survival and lung function in these patients. There were 17 single-lung transplants (SLT), 21 double-lung transplants (DLT) and 1 heart-lung transplant (HLT). Seven patients died during the period, giving an overall survival of 82%. One-year survival according to Kaplan-Meier survival analysis was 87%, and 2-year survival was 83%. Vital capacity and forced expiratory volume in 1 s (FEV1) 1 year after transplantation were 91% and 100% of predicted, respectively, in the DLT group and 60% and 50% in the SLT group. Bronchiolitis obliterans syndrome (BOS) developed in 11 of the 35 patients (31%) surviving more than 6 months, 2/21 in the DLT group and 8/13 in the SLT group and in the patient with HLT. The median time until detection of BOS was 11 months after the operation (range 6-18 months). Working capacity 1 year after transplantation was 60% of predicted in the DLT group and 47% of predicted in the SLT group. Ventilatory capacity was no longer function limiting. Lung transplantation today is a therapeutic option with a good medium-term survival and good functional results in selected patients with severe lung disease. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|