Pathway Engineering of Anthracyclines: Blazing Trails in Natural Product Glycodiversification
| Autor: | Mikko Metsä-Ketelä, Benjamin Nji Wandi, Katelyn V. Brown, S. Eric Nybo |
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| Rok vydání: | 2020 |
| Předmět: |
0303 health sciences
Biological Products Natural product Glycosylation biology 010405 organic chemistry Chemistry Topoisomerase Organic Chemistry Glycosyltransferases 01 natural sciences Article 0104 chemical sciences 3. Good health 03 medical and health sciences chemistry.chemical_compound Biochemistry Polyketides Cancer cell biology.protein Anthracyclines human activities DNA 030304 developmental biology Pathway engineering |
| Zdroj: | J Org Chem |
| ISSN: | 1520-6904 |
| Popis: | The anthracyclines are structurally diverse anticancer natural products that bind to DNA and poison the topoisomerase II – DNA complex in cancer cells. Rational modifications in the deoxysugar functionality are especially advantageous for synthesizing drugs with improved potency. Combinatorial biosynthesis of glycosyltransferases and deoxysugar synthesis enzymes is indispensable for the generation of glycodiversified anthracyclines. This Synopsis considers recent advances in glycosyltransferase structural biology and site-directed mutagenesis, pathway engineering, and deoxysugar combinatorial biosynthesis with a focus on the generation of “new-to-nature” anthracycline analogs. |
| Databáze: | OpenAIRE |
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