Immunodeficiency with increased immunoglobulin M associated with growth hormone insufficiency
| Autor: | Takehiko Ohzeki, H Hayashibara, Hiroko Motozumi, Keiichi Hanaki, H Emura, Y Tsuji, Kazuo Shiraki, Y Harada, M Okamoto, Hiroko Ohtahara |
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| Rok vydání: | 1993 |
| Předmět: |
Male
medicine.medical_specialty Hyper IgM syndrome Adolescent medicine.medical_treatment Short stature Growth hormone deficiency Hypogammaglobulinemia Hypergammaglobulinemia Internal medicine medicine Humans Growth Disorders Immunodeficiency biology business.industry Insulin Immunologic Deficiency Syndromes General Medicine medicine.disease Pedigree Endocrinology Immunoglobulin M Growth Hormone Pediatrics Perinatology and Child Health biology.protein medicine.symptom Antibody business Hormone |
| Zdroj: | Acta Paediatrica. 82:620-623 |
| ISSN: | 1651-2227 0803-5253 |
| DOI: | 10.1111/j.1651-2227.1993.tb12773.x |
| Popis: | Growth hormone deficiency associated with hypogammaglobulinemia has been reported only in a few publications. Our patient was a male with recurrent episodes of infections. Serum immunoglobulin (Ig) G was extremely low although IgM concentration was much greater than the normal limit. Growth hormone responses to insulin, 1-Dopa and growth hormone-releasing hormone were low. The mean growth hormone concentration during sleep was less than the normal limit. These results are consistent with hyper-IgM immunodeficiency associated with growth hormone deficiency. The mode of transmission appears to be autosomal dominant. This combination has not been reported previously. |
| Databáze: | OpenAIRE |
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