Deoxyribonucleic Acid Repair Activity Is Associated with Healed Coronary Plaque Rupture by Optical Coherence Tomography

Autor: Nikunj Shah, Michael Mahmoudi, Paul Kolm, Nick Curzen, Martin R. Bennett, Kazuhiro Dan, Hector M. Garcia-Garcia, Kayode O. Kuku, Omar Yacob, Ron Waksman
Rok vydání: 2019
Předmět:
0301 basic medicine
medicine.medical_specialty
DNA Ligases
DNA Repair
DNA repair
Population
Pharmaceutical Science
DNA ligase activity
030204 cardiovascular system & hematology
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Predictive Value of Tests
Internal medicine
Genetics
medicine
Humans
Angina
Stable
Prospective Studies
Myocardial infarction
Non-ST Elevated Myocardial Infarction
education
Pathological
Genetics (clinical)
chemistry.chemical_classification
Wound Healing
DNA ligase
education.field_of_study
Rupture
Spontaneous
business.industry
medicine.disease
Plaque
Atherosclerotic
030104 developmental biology
medicine.anatomical_structure
chemistry
Cardiology
Molecular Medicine
Cardiology and Cardiovascular Medicine
business
Tomography
Optical Coherence
DNA
Artery
Zdroj: Journal of Cardiovascular Translational Research. 12:608-610
ISSN: 1937-5395
1937-5387
DOI: 10.1007/s12265-019-09904-2
Popis: Deoxyribonucleic acid (DNA) damage and repair signaling cascades are related to the development of atherosclerosis. Pathological studies have demonstrated that healed coronary plaque rupture (HCPR) contributes to plaque progression and predisposes to sudden ischemic cardiac death. The objective of this study is to investigate the relationship between HCPR detected by optical coherence tomography (OCT) and DNA ligase. Forty-two patients with both OCT and DNA ligase were prospectively enrolled. The population included patients with stable angina pectoris (SA) and non-ST-elevation myocardial infarction (NSTEMI). It was found that the prevalence of HCPR was greater in subjects with higher DNA ligase activity (correlation coefficient 0.36, p = 0.019). The presence of HCPR in patients with NSTEMI was greater than in patients with SA per OCT analysis; however, there was no statistical difference in this limited population (22.53% versus 12.83%, respectively, p = 0.116). DNA repair activity by DNA ligase was associated with HCPR in advanced coronary artery plaque by OCT.
Databáze: OpenAIRE
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