Age-Related Changes in the Reliability of Antioxidant Enzyme Defense in Monkeys with Different Types of Adaptive Behavior
| Autor: | N. D. Goncharova, Victor Yu. Marenin, Arsen A. Vengerin |
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| Rok vydání: | 2013 |
| Předmět: |
Pulmonary and Respiratory Medicine
Aging medicine.medical_specialty Antioxidant medicine.medical_treatment Biology Reductase Thiobarbituric Acid Reactive Substances Antioxidants Lipid peroxidation Basal (phylogenetics) chemistry.chemical_compound Internal medicine medicine TBARS Animals Glutathione Transferase chemistry.chemical_classification Adaptive behavior Glutathione Peroxidase Depression Glutathione peroxidase Adaptation Physiological Macaca mulatta Disease Models Animal Glutathione Reductase Enzyme Endocrinology chemistry Pediatrics Perinatology and Child Health Immunology Female Lipid Peroxidation Stress Psychological |
| Zdroj: | Current Aging Science. 6:163-169 |
| ISSN: | 1874-6098 |
| DOI: | 10.2174/18746098112059990004 |
| Popis: | We have investigated age-related changes in the reliability of glutathione-related antioxidant enzyme defense in monkeys that differ in adaptive behavior. Activities of gluthatione reductase (GR), glutathione peroxidase (GSH-Px), and gluthatione-S-transferase (GST) and also lipid peroxidation products (TBARS) under basal conditions and under acute psycho-emotional stress were evaluated in erythrocytes of young (6-8 years) and old (20-27 years) female rhesus monkeys with depression-like and standard (control) behavior. We have found that young animals with depression-like behavior, in comparison with young monkeys of standard behavior, demonstrated higher activity of GR in basal conditions and no significant changes in response to acute immobilization stress. With aging the activity of GR increased in monkeys with standard behavior in basal conditions but retained the ability to increase under acute stress. At the same time during aging in monkeys with depression-like behavior GR activity did not undergo significant changes in basal conditions and did not change in response to acute stress. Moreover, old animals with depression-like behavior demonstrated reduced activity of GSH-Px. More pronounced disturbances in GR and GSH-Px activities in animals with depression-like behavior evidence a more marked decrease in the reliability of antioxidant enzyme defense of cells and lead to activation of lipid peroxidation that may be considered as an important factor of aging. Thus, age-related dysfunctions of the antioxidant enzyme system correlate with the type of adaptive behavior characteristic of animals. |
| Databáze: | OpenAIRE |
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