A direct test of the diathesis–stress model for depression
Autor: | Lucía Colodro-Conde, Margaret J. Wright, Scott D. Gordon, Nicholas G. Martin, William L. Coventry, Lindon J. Eaves, Sarah E. Medland, Stephan Ripke, Gu Zhu, Naomi R. Wray, Baptiste Couvy-Duchesne, Enda M. Byrne, A. C. Heath, P. A. F. Madden, Grant W. Montgomery |
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Rok vydání: | 2017 |
Předmět: |
Adult
Male Multifactorial Inheritance medicine.medical_specialty Vulnerability Life Change Events 03 medical and health sciences Cellular and Molecular Neuroscience Social support 0302 clinical medicine Risk Factors medicine Humans Genetic Predisposition to Disease Psychiatry Molecular Biology Depression (differential diagnoses) Depressive Disorder Major Depression Stressor Diathesis Middle Aged medicine.disease Explained variation 030227 psychiatry Diathesis–stress model Psychiatry and Mental health Major depressive disorder Female Gene-Environment Interaction Disease Susceptibility medicine.symptom Psychology 030217 neurology & neurosurgery Genome-Wide Association Study Clinical psychology |
Zdroj: | Colodro-Conde, L, Couvy-Duchesne, B, Zhu, G, Coventry, W L, Byrne, E M, Gordon, S, Wright, M J, Montgomery, G W, Madden, P A F, Ripke, S, Eaves, L J, Heath, A C, Wray, N R, Medland, S E, Martin, N G & Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium 2018, ' A direct test of the diathesis-stress model for depression ', Molecular Psychiatry, vol. 23, no. 7, pp. 1590-1596 . https://doi.org/10.1038/mp.2017.130 |
ISSN: | 1476-5578 1359-4184 |
Popis: | The diathesis-stress theory for depression states that the effects of stress on the depression risk are dependent on the diathesis or vulnerability, implying multiplicative interactive effects on the liability scale. We used polygenic risk scores for major depressive disorder (MDD) calculated from the results of the most recent analysis from the Psychiatric Genomics Consortium as a direct measure of the vulnerability for depression in a sample of 5221 individuals from 3083 families. In the same we also had measures of stressful life events and social support and a depression symptom score, as well as DSM-IV MDD diagnoses for most individuals. In order to estimate the variance in depression explained by the genetic vulnerability, the stressors and their interactions, we fitted linear mixed models controlling for relatedness for the whole sample as well as stratified by sex. We show a significant interaction of the polygenic risk scores with personal life events (0.12% of variance explained, P-value=0.0076) contributing positively to the risk of depression. Additionally, our results suggest possible differences in the aetiology of depression between women and men. In conclusion, our findings point to an extra risk for individuals with combined vulnerability and high number of reported personal life events beyond what would be expected from the additive contributions of these factors to the liability for depression, supporting the multiplicative diathesis-stress model for this disease. |
Databáze: | OpenAIRE |
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