Platelet activating factor-acetylhydrolase (PAF-AH) activity and HDL levels, but not PAF-AH gene polymorphisms, are associated with successful aging in Sicilian octogenarians
| Autor: | Michele Bonaiuto, Alessandra Bitto, Carlo Saitta, Antonio Bonaiuto, Antonino Saitta, Maurizio Cinquegrani, M.A. Sardo, Maria Castaldo, Salvatore Campo, Giuseppe Trimarchi, Simona Cristadoro |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Male Ala379Val Arg92His Ile198Thr Octogenarians PAF-AH activity PAF-AH polymorphisms medicine.medical_specialty Aging Disease Polymorphism Single Nucleotide chemistry.chemical_compound High-density lipoprotein Internal medicine Genotype medicine PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE Humans Gene Aged DNA Primers Aged 80 and over Successful aging Base Sequence business.industry Cholesterol HDL Atherosclerotic disease Age Factors Atherosclerosis Surgery Endocrinology chemistry Amino Acid Substitution Italy Cardiovascular Diseases Low-density lipoprotein 1-Alkyl-2-acetylglycerophosphocholine Esterase lipids (amino acids peptides and proteins) Female Geriatrics and Gerontology business Lipoproteins HDL |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 1594-0667 |
| Popis: | Background and aims: Aging is associated with an increased risk of developing atherosclerosis. Subjects over 80 years of age without cardiovascular disease provide a model to investigate the protective factors increasing their resistance to atherosclerotic disease. Platelet-activating factor acetylhydrolase (PAF-AH) is an enzyme associated with low density lipoprotein (LDL) and high density lipoprotein (HDL) inactivating platelet-activating factor (PAF) and preventing LDL oxidation by hydrolysis of oxidized phospholipids. The aim of the present study was to evaluate the contribution of the PAF-AH gene Arg92His, Ile198Thr and Ala379Val polymorphisms to resistance toward developing cardiovascular events in healthy Sicilian octogenarians. Methods: Distribution of PAF-AH genotypes and activity, and biochemical parameters, were compared between 100 octogenarians and 200 healthy adults. Results: The individuals in the elderly group displayed significantly higher levels of HDL-C (p |
| Databáze: | OpenAIRE |
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