A Genomewide Admixture Mapping Panel for Hispanic/Latino Populations
| Autor: | Rui Mei, Lorna G. Moore, Paul M. McKeigue, Xianyun Mao, Fabiola León-Velarde, Gerardo Gutiérrez, Esteban J. Parra, Mark D. Shriver, Kenneth M. Weiss, Abigail W. Bigham, Tom D. Brutsaert, Enrique Vargas |
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| Rok vydání: | 2007 |
| Předmět: |
Genetic Markers
Genotype Genetic Linkage Population Genetic admixture Black People Polymorphism Single Nucleotide White People 03 medical and health sciences 0302 clinical medicine Gene mapping Gene Frequency Report medicine Genetics Chromosomes Human Humans Genetics(clinical) Genetic Testing education Genotyping Allele frequency Genetics (clinical) Alleles 030304 developmental biology Genetic testing Oligonucleotide Array Sequence Analysis 0303 health sciences education.field_of_study medicine.diagnostic_test Models Genetic Genome Human Indians South American Chromosome Mapping Hispanic or Latino Indians Central American Geography Genetics Population Genetic distance Genetic marker 030220 oncology & carcinogenesis Indians North American Demography |
| Zdroj: | The American Journal of Human Genetics. 80(6):1171-1178 |
| ISSN: | 0002-9297 |
| DOI: | 10.1086/518564 |
| Popis: | Admixture mapping (AM) is a promising method for the identification of genetic risk factors for complex traits and diseases showing prevalence differences among populations. Efficient application of this method requires the use of a genomewide panel of ancestry-informative markers (AIMs) to infer the population of origin of chromosomal regions in admixed individuals. Genomewide AM panels with markers showing high frequency differences between West African and European populations are already available for disease-gene discovery in African Americans. However, no such a map is yet available for Hispanic/Latino populations, which are the result of two-way admixture between Native American and European populations or of three-way admixture of Native American, European, and West African populations. Here, we report a genomewide AM panel with 2,120 AIMs showing high frequency differences between Native American and European populations. The average intermarker genetic distance is ∼1.7 cM. The panel was identified by genotyping, with the Affymetrix GeneChip Human Mapping 500K array, a population sample with European ancestry, a Mesoamerican sample comprising Maya and Nahua from Mexico, and a South American sample comprising Aymara/Quechua from Bolivia and Quechua from Peru. The main criteria for marker selection were both high information content for Native American/European ancestry (measured as the standardized variance of the allele frequencies, also known as “f value”) and small frequency differences between the Mesoamerican and South American samples. This genomewide AM panel will make it possible to apply AM approaches in many admixed populations throughout the Americas. |
| Databáze: | OpenAIRE |
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