A randomised controlled trial comparing the efficacy of micellised and fat-soluble vitamin D3 supplementation in healthy adults
| Autor: | Navin Dang, Ambrish Mittal, Anne Singh, Aditi Chadha, Raman K. Marwaha, Tanvi Dev, Kalaivani Mani, Meetu Goel, Archna Narang, Preeti Arora, Gomathy Sethuraman, Vinod Sharma |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Vitamin Adult Male medicine.medical_specialty Hypercalcaemia Medicine (miscellaneous) Parathyroid hormone India 030209 endocrinology & metabolism law.invention Body Mass Index 03 medical and health sciences chemistry.chemical_compound Young Adult 0302 clinical medicine Randomized controlled trial law Internal medicine medicine Humans Hypercalciuria Micelles Calcifediol Cholecalciferol Creatinine Drug Carriers 030109 nutrition & dietetics Nutrition and Dietetics business.industry Middle Aged medicine.disease Vitamin D Deficiency Healthy Volunteers Endocrinology Fat-Soluble Vitamin Nanomedicine chemistry Solubility Parathyroid Hormone Dietary Supplements Alkaline phosphatase Female business |
| Zdroj: | The British journal of nutrition. 121(8) |
| ISSN: | 1475-2662 |
| Popis: | Nanoemulsion formulation of vitamin D3 have been shown to have better bioavailability than the coarse emulsion preparation in vitro and in vivo animal studies. In the absence of randomised trial in humans, comparing the efficacy of nanotechnology-based miscellised vitamin D3 over conventional vitamin D3, we undertook this study. A total of 180 healthy adults were randomised to receive either micellised (DePura, group A) or conventional vitamin D3 (Calcirol, group B) at a monthly dose of 60 000 IU (1500μg) for 6 months. The outcome parameters were serum 25-hydroxyvitamin D (25(OH)D), parathyroid hormone (PTH), Ca, phosphate, alkaline phosphatase and urinary Ca:creatinine ratio. A total of eighty-nine subjects in group A and seventy-seven in group B completed the trial. Subjects in both the groups had a significant increase in their serum 25(OH)D levels following supplementation (group A: 21·5 (sd 10·9) to 76·7 (sd 18·8) nmol/l (Psd 10·4) to 57·8 (sd 16·0) nmol/l (PPP3 appeared to be more efficacious in achieving higher levels of serum 25(OH)D. |
| Databáze: | OpenAIRE |
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