Calcium tracer kinetics show decreased irreversible flow to bone in glucocorticoid treated patients
| Autor: | Alfred L. Yergey, Steven A. Abrams, Maria D. Perez, R. E. Goans, George H. Weiss |
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| Rok vydání: | 1995 |
| Předmět: |
Calcium Isotopes
Male medicine.medical_specialty Adolescent Endocrinology Diabetes and Metabolism Kinetics Indicator Dilution Techniques chemistry.chemical_element Calcium Models Biological Bone and Bones Dermatomyositis Isotopes of calcium Endocrinology Prednisone Internal medicine medicine Humans Orthopedics and Sports Medicine Child Glucocorticoids Juvenile dermatomyositis Calcium metabolism Osteoblasts Chemistry medicine.disease Osteopenia Bone Diseases Metabolic Female Glucocorticoid medicine.drug |
| Zdroj: | Calcified Tissue International. 56:533-535 |
| ISSN: | 1432-0827 0171-967X |
| Popis: | Osteopenia resulting from pharmacologic doses of glucocorticoids is well known. Previously, there has been no satisfactory quantitative model describing the kinetics of calcium flow in subjects on chronic steroid use. A mathematical model of calcium isotope interaction with bone is described and applied to determine an estimate of kinetic parameters characterizing these changes. Calcium tracer dilution kinetics after a bolus injection of 42Ca were measured in 14 subjects with juvenile dermatomyositis, 6 on prednisone regimens and 8 on treatment regimens without prednisone. Irreversible tracer loss from plasma bone is found to be significantly reduced (P = 0.043) in the glucocorticoid-treated patients compared with patients on nonsteroid regimens. Reversible flow to bone is noted to be similar in the two groups. These results suggest a direct effect of glucocorticoids on osteoblast function. |
| Databáze: | OpenAIRE |
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