Viral Infection Modulates Mitochondrial Function
Autor: | Hongxing Ding, Lin Yi, Jinding Chen, Jindai Fan, Shuangqi Fan, Mingqiu Zhao, Sen Zeng, Zhaoyao Li, Xiaowen Li, Keke Wu, Feifan Zhao |
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Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
0301 basic medicine
Programmed cell death QH301-705.5 Review Biology Mitochondrion Mitochondrial Dynamics Catalysis Virus Inorganic Chemistry 03 medical and health sciences Immune system Organelle virus infection Animals Humans Physical and Theoretical Chemistry host innate immunity Biology (General) mitochondrial fission and fusion Molecular Biology QD1-999 Spectroscopy Immunity Cellular Innate immune system 030102 biochemistry & molecular biology Organic Chemistry apoptosis General Medicine Immunity Innate Computer Science Applications Cell biology Mitochondria Chemistry 030104 developmental biology Apoptosis Intracellular |
Zdroj: | International Journal of Molecular Sciences, Vol 22, Iss 4260, p 4260 (2021) International Journal of Molecular Sciences |
ISSN: | 1661-6596 1422-0067 |
Popis: | Mitochondria are important organelles involved in metabolism and programmed cell death in eukaryotic cells. In addition, mitochondria are also closely related to the innate immunity of host cells against viruses. The abnormality of mitochondrial morphology and function might lead to a variety of diseases. A large number of studies have found that a variety of viral infections could change mitochondrial dynamics, mediate mitochondria-induced cell death, and alter the mitochondrial metabolic status and cellular innate immune response to maintain intracellular survival. Meanwhile, mitochondria can also play an antiviral role during viral infection, thereby protecting the host. Therefore, mitochondria play an important role in the interaction between the host and the virus. Herein, we summarize how viral infections affect microbial pathogenesis by altering mitochondrial morphology and function and how viruses escape the host immune response. |
Databáze: | OpenAIRE |
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