Low doses of eriocitrin attenuate metabolic impairment of glucose and lipids in ongoing obesogenic diet in mice
| Autor: | Luis Carlos Spolidório, Paula Scanavez Ferreira, Thais Borges Cesar, Marina S. Nery, John A. Manthey |
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| Přispěvatelé: | Universidade Estadual Paulista (Unesp), Usda |
| Rok vydání: | 2020 |
| Předmět: |
Blood Glucose
Male 0301 basic medicine medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment 030204 cardiovascular system & hematology Diet High-Fat medicine.disease_cause Lipid peroxidation Mice Random Allocation 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Blood serum Internal medicine medicine Animals Eriocitrin Obesity Nutrition and Dietetics Systemic inflammation business.industry Insulin Metabolism and Metabolic Studies food and beverages Metabolism medicine.disease Lipids Mice Inbred C57BL 030104 developmental biology Endocrinology chemistry Oxidative stress Flavanones Resistin business Research Article Food Science |
| Zdroj: | Scopus Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP Journal of Nutritional Science |
| ISSN: | 2048-6790 |
| DOI: | 10.1017/jns.2020.52 |
| Popis: | Made available in DSpace on 2021-06-25T10:18:11Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-01-01 Eriocitrin is a citrus flavonoid with a high capacity to reduce the oxidative stress related to metabolic disorders and obesity. We assessed the effects of low doses of eriocitrin on the oxidative stress, inflammation, and metabolism of glucose and lipids of high-fat diet (HFD)-fed obese mice. Fifty male C57BL/6J mice were randomly assigned into five groups (n 10). The mice were fed an HFD (45 % kcal from fat, i.e. lard) for 4 weeks for obesity induction. After this period, the mice continued receiving the same HFD, but supplemented with eriocitrin at 10, 25 or 100 mg/kg body weight (bw) for an additional 4 weeks. Control groups were fed with standard diet (10 % kcal of fat, i.e. soy oil) or with HFD without eriocitrin, for eight consecutive weeks. At the end of the study, mice supplemented with eriocitrin showed lower levels of blood serum glucose and blood and liver triacylglycerols (P < 0â.05). There was also improved levels of insulin, HOMA-IR, total-cholesterol, resistin and lipid peroxidation in the supplemented mice. It was concluded that the 25 mg dose of eriocitrin improved all the parameters studied and had positive effects on oxidative stress, systemic inflammation and metabolism of lipids and glucose in general. Laboratory of Nutrition School of Pharmaceutical Sciences Sao Paulo State University-UNESP U.S. Horticultural Research Laboratory Agricultural Research Service Usda, 1401 South Rock Road/Port Fierce Laboratory of Pathology School of Dentistry Unesp Sao Paulo State University Laboratory of Nutrition School of Pharmaceutical Sciences Sao Paulo State University-UNESP Laboratory of Pathology School of Dentistry Unesp Sao Paulo State University |
| Databáze: | OpenAIRE |
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