Cervical node metastases in early squamous cell carcinoma of the floor of the mouth: Predictive value of multiple histopathologic parameters

Autor: Kumao Sako, Donald P. Shedd, Nieva B. Castillo, Richard W. Nason
Rok vydání: 1990
Předmět:
Zdroj: World Journal of Surgery. 14:606-609
ISSN: 1432-2323
0364-2313
DOI: 10.1007/bf01658802
Popis: A semiquantitative assessment of multiple histological parameters was applied retrospectively to 66 patients with stage I and II squamous cell carcinoma of the floor of the mouth to determine if prognostic information relative to cervical node metastases could be obtained. Three parameters relating to the tumor cell population and 5 describing the tumor-host interface were evaluated on a point scale from 1 to 3 with the highest score going to the most threatening characteristic. Twenty of the 66 patients had either occult metastases identified by elective lymphadenectomy (n = 11) or developed metastases to the neck (n = 9). There was no correlation between traditional histological grading as recorded at the time of presentation and the frequency of cervical metastases (p greater than 0.05). Histological reevaluation defined 3 groups of patients with low (less than 14), moderate (14-16), and high scores (greater than 16) with an incidence of cervical metastases of 5/39 (12.8%), 6/17 (35.3%), and 9/10 (90%), respectively (p less than 0.001). The results suggest that microscopic grading could be a useful adjunct to the present TNM staging system in selecting patients likely to benefit from elective treatment of the neck.
Databáze: OpenAIRE
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