Synthesis and Cytotoxic Activity of 1-{3-[1-(5-Organylsilylfuran-2-yl)silinan-1-yl]propyl}amines and Some Trimethylgermyl Analogues

Autor:	Luba Ignatovich, Ilze Sleiksha, I. Shestakova, Jury Popelis, Vitalijs Romanovs, Velta Muravenko
Rok vydání:	2014
Předmět:	Germanium Stereochemistry Hydrosilylation Organic Chemistry Substituent Antineoplastic Agents General Chemistry Ring (chemistry) Methylation Catalysis Mice chemistry.chemical_compound chemistry Cell Line Tumor Neoplasms Furan NIH 3T3 Cells Animals Humans Cytotoxic T cell Organosilicon Compounds Amine gas treating Cytotoxicity
Zdroj:	Chemistry - A European Journal. 20:12786-12788
ISSN:	0947-6539
DOI:	10.1002/chem.201402865
Popis:	New highly cytotoxic 1-{3-[1-(5-organylsilyl-furan-2-yl)silinan-1-yl]propyl}amines and some trimethylgermyl analogues (IC50 1-7 μg mL(-1)) have been synthesized by a hydrosilylation reaction of aliphatic and heterocyclic N-allylamines in the presence of Speier's catalyst. The effects of the silacycle, the element-organic substituent in position 5 of the furan ring, and the structure of the amine on the cytotoxicity of the new compounds have been studied.
Databáze:	OpenAIRE
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