Efficacy of β-lactams against experimental pneumococcal endocarditis caused by strains with different susceptibilities to penicillin
| Autor: | Jerónimo Pachón, Fernando Docobo-Pérez, C. Pichardo, Ignacio Moreno-Maqueda, Manuel E. Jiménez-Mejías, A. García-Curiel, María Eugenia Pachón-Ibáñez, F. Javier Caballero-Granado |
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| Rok vydání: | 2005 |
| Předmět: |
Microbiology (medical)
Cefotaxime Penicillin Resistance Microbial Sensitivity Tests Penicillins beta-Lactams medicine.disease_cause Pneumococcal Infections Microbiology Antibiotic resistance Streptococcus pneumoniae polycyclic compounds medicine Animals Pharmacology (medical) Antibacterial agent Pharmacology business.industry Ceftriaxone Endocarditis Bacterial Amoxicillin medicine.disease Anti-Bacterial Agents Penicillin Pneumococcal infections Infectious Diseases Rabbits business Half-Life medicine.drug |
| Zdroj: | Journal of Antimicrobial Chemotherapy. 56:732-737 |
| ISSN: | 1460-2091 0305-7453 |
| DOI: | 10.1093/jac/dki304 |
| Popis: | OBJECTIVES To compare the in vitro and in vivo activity of penicillin, cefotaxime and ceftriaxone, using three strains of Streptococcus pneumoniae with different susceptibilities to penicillin (MICs of 0.015, 0.25 and 2 mg/L, respectively). METHODS Time-kill curves and an experimental model of endocarditis in rabbits. RESULTS Penicillin was efficacious in clearing bacteria from vegetations and blood irrespective of whether infections were caused by penicillin-susceptible or penicillin-resistant strains (P < 0.01 with respect to control groups). The same efficacy was shown with cefotaxime and ceftriaxone. Comparing the results of the in vivo model with those obtained in time-kill curves, penicillin showed the best results. CONCLUSIONS These results confirm that penicillin is efficacious in the treatment of pneumococcal infections, including those produced by strains with MICs < or = 2 mg/L (with the exception of pneumococcal meningitis). These results also suggest that the breakpoints to define susceptibility and resistance of S. pneumoniae to penicillin must be reviewed, as has been done with amoxicillin and third-generation cephalosporins. |
| Databáze: | OpenAIRE |
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