Advances in research on the regulatory mechanism of NHE1 in tumors
| Autor: | Jingyu Xu, Yanxia Hu, Jun Lou, Qian Du, Rui Xie, Weixi Shan, Xiaoxu Yang, Zhe Jin, Qiushi Liao |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
signaling pathway Cancer Research Tumor microenvironment Modern medicine Chemistry Cell growth Na+/H+ exchanger isoform 1 Review Cell cycle Membrane transport Cell biology 03 medical and health sciences 030104 developmental biology 0302 clinical medicine intracellular and extracellular pH Oncology 030220 oncology & carcinogenesis Extracellular tumor microenvironment cancer Signal transduction Intracellular |
| Zdroj: | Oncology Letters |
| ISSN: | 1792-1082 1792-1074 |
| Popis: | Tumors pose a major threat to human health and present with difficulties that modern medicine has yet to overcome. It has been demonstrated that the acid-base balance of the tumor microenvironment is closely associated with the dynamic balance in the human body and that it regulates several processes, such as cell proliferation and differentiation, intracellular enzyme activity, and cytoskeletal assembly and depolymerization. It has been well established that the regulation of intra- and extracellular pH depends on a series of functional ion transporters and hydrogen ion channels, such as the Na+/H+ exchanger (NHE) protein and thee Cl/HCO3- exchange protein, among which the NHE1 member of the NHE family has been attracting increasing attention in recent years, particularly in studies on the correlation between pH regulation and tumors. NHE1 is a housekeeping gene encoding a protein that is widely expressed on the surface of all plasma membranes. Due to its functional domain, which determines the pHi at its N-terminus and C-terminus, NHE1 is involved in the regulation of the cellular pH microenvironment. It has been reported in the literature that NHE1 can regulate cell volume, participate in the transmembrane transport of intracellular and extracellular ions, affect cell proliferation and apoptosis, and regulate cell behavior and cell cycle progression; however, research on the role of NHE1 in tumorigenesis and tumor development in various systems is at its early stages. The aim of the present study was to review the current research on the correlation between the NHE family proteins and various systemic tumors, in order to indicate a new direction for antitumor drug development with the pH microenvironment as the target. |
| Databáze: | OpenAIRE |
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