METHYLATION OF CHROMOSOME 11P GENES IN WILMS-TUMOR AND KIDNEY TISSUE
| Autor: | Mg Mott, Nj Maitland, KN Brown, Jc Williams |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Cancer Research
Kidney animal structures endocrine system diseases urogenital system Cancer Chromosome Wilms' tumor Methylation Biology medicine.disease medicine.disease_cause Molecular biology female genital diseases and pregnancy complications medicine.anatomical_structure Oncology medicine Cancer research HRAS Genomic imprinting Carcinogenesis |
| Zdroj: | International Journal of Oncology. 1:743-746 |
| ISSN: | 1791-2423 1019-6439 |
| DOI: | 10.3892/ijo.1.7.743 |
| Popis: | Three genes on the short arm of chromosome 11 (WT1, IGF2 and HRAS) were hypomethylated in Wilms' tumour tissue compared to normal kidney tissue, and one (CALCA) was hypermethylated. IGF2 and HRAS showed evidence of allele-specific methylation, which may indicate genomic imprinting of the 11p15 region in some kidney cells. |
| Databáze: | OpenAIRE |
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