Anti-inflammatory procyanidins and triterpenes in 109 apple varieties
| Autor: | Christelle M. Andre, Danièle Evers, Nigel B. Perry, Edward G Walker, Maysoon Rassam, Jeffrey M Greenwood, William A. Laing, Michael L. Sullivan |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
medicine.drug_class
Anti-Inflammatory Agents Biology Anti-inflammatory Terpene Promoter activity Triterpene medicine Humans Proanthocyanidins Cultivar Food science Chromatography High Pressure Liquid chemistry.chemical_classification Tumor Necrosis Factor-alpha Flesh NF-kappa B General Chemistry Triterpenes Inflammation Process HEK293 Cells Proanthocyanidin chemistry Biochemistry Malus General Agricultural and Biological Sciences |
| Zdroj: | Journal of agricultural and food chemistry. 60(42) |
| ISSN: | 1520-5118 |
| Popis: | We evaluated the potential of apple to reduce inflammation. Phenolic compounds and triterpenes were analyzed in 109 apple cultivars. Total phenolics ranged from 29 to 7882 μg g(-1) of fresh weight (FW) in the flesh and from 733 to 4868 μg g(-1) FW in the skin, with flavanols including epicatechin and procyanidins as major components. Ursolic (44.7 to 3522 μg g(-1) FW) and oleanolic (47.2 to 838 μg g(-1) FW) acids dominated the skin triterpene profile. Five chemically contrasting cultivars were fractionated and their immune-modulating activity measured using two cell-based assays targeting key points in the inflammation process. Cultivars exhibiting high contents of procyanidins were the most potent at inhibiting NF-κB while triterpene-rich fractions reduced the promoter activity of the gene of TNFα. This study provides new insights into how apple genetic diversity could be used to alleviate inflammation. |
| Databáze: | OpenAIRE |
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