Synthesis rates of total liver protein and albumin are both increased in patients with an acute inflammatory response
| Autor: | Maria Klaude, Olav Rooyackers, Folke Hammarqvist, Jan Wernerman, Bo Westman, Peter J. Garlick, H. Barle |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment Inflammation Phenylalanine Gastroenterology Intraoperative Period Internal medicine Cholecystitis medicine Humans Serum Albumin Aged Anthropometry biology medicine.diagnostic_test business.industry Catabolism Albumin General Medicine Middle Aged biology.organism_classification medicine.disease Endocrinology Cholecystectomy Laparoscopic Liver Protein Biosynthesis Tasa Liver biopsy Acute Disease Female Cholecystectomy medicine.symptom business |
| Zdroj: | Clinical Science. 110:93-99 |
| ISSN: | 1470-8736 0143-5221 |
| DOI: | 10.1042/cs20050222 |
| Popis: | The general perception that catabolism and inflammation are associated with a high synthesis rate of total liver protein and a low albumin synthesis rate has been challenged in recent years by several studies in man, indicating that the synthesis rate of albumin in response to a catabolic insult is increased rather than decreased. Thus changes in liver protein synthesis rates in conjunction with catabolism and acute inflammation in man need to be characterized better. The aim of the present study was to measure protein synthesis rates of total liver protein and albumin during a state of acute inflammation. Patients (n=10) undergoing acute laparoscopic cholecystectomy due to acute cholecystitis were investigated. FSRs (fractional synthesis rates) of total liver protein (liver biopsy specimens) and albumin (plasma samples) were investigated as early as possible during the surgical procedure, using a flooding dose of L-[2H5]phenylalanine. The results were compared with a reference group of patients without cholecystitis undergoing elective laparoscopic cholecystectomy (n=17). FSR of total liver protein was 60% higher (P |
| Databáze: | OpenAIRE |
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