From Blood to Regenerative Tissue: How Autologous Platelet-Rich Fibrin Can Be Combined with Other Materials to Ensure Controlled Drug and Growth Factor Release
| Autor: | Ilze Šalma, Karina Egle, Arita Dubnika |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Blood Platelets
Drug Biocompatibility QH301-705.5 media_common.quotation_subject platelet-rich fibrin endogenous growth factors autologous growth factors Review Regenerative Medicine Bone tissue Catalysis Fibrin Inorganic Chemistry Tissue engineering Humans Medicine Biology (General) Physical and Theoretical Chemistry QD1-999 Molecular Biology Spectroscopy media_common carrier systems drug delivery platelet concentrates tissue engineering biology Platelet-Rich Plasma business.industry Organic Chemistry Soft tissue General Medicine Platelet-rich fibrin Computer Science Applications Chemistry medicine.anatomical_structure Drug delivery biology.protein Intercellular Signaling Peptides and Proteins business Biomedical engineering |
| Zdroj: | International Journal of Molecular Sciences, Vol 22, Iss 11553, p 11553 (2021) Int. J. Mol. Sci. International Journal of Molecular Sciences |
| ISSN: | 1422-0067 |
| Popis: | The purpose of this review is to examine the latest literature on the use of autologous platelet-rich fibrin as a drug and growth factor carrier system in maxillofacial surgery. Autologous platelet-rich fibrin (PRF) is a unique system that combines properties such as biocompatibility and biodegradability, in addition to containing growth factors and peptides that provide tissue regeneration. This opens up new horizons for the use of all beneficial ingredients in the blood sample for biomedical purposes. By itself, PRF has an unstable effect on osteogenesis: therefore, advanced approaches, including the combination of PRF with materials or drugs, are of great interest in clinics. The main advantage of drug delivery systems is that by controlling drug release, high drug concentrations locally and fewer side effects within other tissue can be achieved. This is especially important in tissues with limited blood supply, such as bone tissue compared to soft tissue. The ability of PRF to degrade naturally is considered an advantage for its use as a “warehouse” of controlled drug release systems. We are focusing on this concentrate, as it is easy to use in manipulations and can be delivered directly to the surgical site. The target audience for this review are researchers and medical doctors who are involved in the development and research of PRFs further studies. Likewise, surgeons who use PRF in their work to treat patients and who advice patients to take the medicine orally. |
| Databáze: | OpenAIRE |
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