Influence of dialysis membrane composition on plasma bisphenol A levels during online hemodiafiltration

Autor: Esther Civantos, Vanesa Camarero, Jesús Egido, Emilio González-Parra, Pedro Abaigar, Sebastian Mas, Didier Sanchez-Ospina, Enrique Bosch-Panadero, Ignacio Mahillo, Alberto Ortiz, Alberto Ruiz-Priego
Přispěvatelé: UAM. Departamento de Medicina, Instituto de Investigación Sanitaria Fundación Jiménez Díaz (IIS-FJD)
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Male
Polymers
Physiology
030232 urology & nephrology
lcsh:Medicine
030204 cardiovascular system & hematology
Toxicology
Pathology and Laboratory Medicine
Dialysis tubing
Bisphenol A
0302 clinical medicine
Chronic Kidney Disease
Medicine and Health Sciences
Toxins
Dialysis membranes
Membrane Technology
Prospective Studies
Sulfones
lcsh:Science
Cross-Over Studies
Multidisciplinary
Online hemodiafiltration
Body Fluids
Separation Processes
Chemistry
Blood
Nephrology
Physical Sciences
Engineering and Technology
Female
Anatomy
Research Article
Online hemodiafiltration (OL-HDF)
Pollutants
medicine.medical_specialty
Medicina
Toxic Agents
Hemodiafiltration
Research and Analysis Methods
Blood Plasma
03 medical and health sciences
Phenols
Renal Dialysis
Medical Dialysis
medicine
Humans
Environmental Chemistry
Benzhydryl Compounds
Gynecology
Molecular Dialysis
business.industry
Ecology and Environmental Sciences
lcsh:R
Biology and Life Sciences
Membranes
Artificial
Membrane Dialysis
Kidney Failure
Chronic
lcsh:Q
Hemofiltration
business
Filtration
Zdroj: PLoS ONE, Vol 13, Iss 3, p e0193288 (2018)
PLoS ONE
Biblos-e Archivo. Repositorio Institucional de la UAM
instname
ISSN: 1932-6203
Popis: Introduction: Bisphenol A (BPA) is an ubiquitous environmental toxin that is also found in dialyzers. Online hemodiafiltration (OL-HDF) more efficiently clears high molecular weight molecules, and this may improve BPA clearance. However, the BPA contents of dialysis membranes may be a source of BPA loading during OL-HDF. Methods A prospective study assessed plasma BPA levels in OL-HDF patients using BPA-free (polynephron) or BPA-containing (polysulfone) dialyzers in a crossover design with two arms, after a run-in OL-HDF period of at least 6 months with the same membrane: 31 patients on polynephron at baseline were switched to polysulfone membranes for 3 months (polynephron-to-polysulfone) and 29 patients on polysulfone were switched to polynephron for 3 months (polysulfone-to-polynephron). Results After a run-in OL-HDF period of at least 6 months with the same membrane, baseline predialysis BPA was lower in patients on polynephron (8.79±7.97 ng/ml) than in those on polysulfone (23.42±20.38 ng/mL, p < 0.01), but still higher than in healthy controls ( < 2 ng/mL). After 3 months of polynephron-to-polysulfone switch, BPA was unchanged (8.98±7.88 to 11.14±15.98 ng/mL, ns) while it decreased on the polysulfone-to-polynephron group (23.42±20.38 to 11.41±12.38 ng/mL, p < 0.01). Conclusion OL-HDF for 3 months with BPA-free dialyzer membranes was associated to a significant decrease in predialysis BPA levels when compared to baseline BPA levels while on a BPA-containing membrane
The Renal, Vascular and Diabetes Laboratory is funded by Ministerio de Economia, Industria y competitividad: FIS ISCIII FEDER funds PI16/01298, PI15/00298, PI16/02057, PI16/01900, SCIII-RETIC REDinREN RD12/0021 RD16/0009, CYTED IBERERC and Sociedad Madrileña de Nefrologia, Programa Intensificación Actividad Investigadora (ISCIII) to AO. This work was supported by a grant from Nipro corporation, and Fundacioón Renal Íñigo Álvarez de Toledo (FRIAT)
Databáze: OpenAIRE
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