Changes in periprosthetic bone mineral density and bone turnover markers after osseointegrated implant surgery: A cohort study of 20 transfemoral amputees with 30-month follow-up

Autor: Klaus Kjær Petersen, Peter Holmberg Jørgensen, Maiken Stilling, Rehne Lessmann Hansen, Bente L. Langdahl, Kjeld Søballe
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Male
030506 rehabilitation
bone turnover
Periprosthetic
AMPUTATION PROSTHESES
Health Professions (miscellaneous)
Bone remodeling
Absorptiometry
Photon
0302 clinical medicine
Bone Density
QUALITY-OF-LIFE
FIXATION
Femur
Prospective Studies
skin and connective tissue diseases
Bone mineral
RISK
Bone-Anchored Prosthesis
Rehabilitation
Treatment options
Middle Aged
Female
Bone Remodeling
0305 other medical science
Cohort study
Month follow up
Adult
REHABILITATION
medicine.medical_specialty
Adolescent
Artificial Limbs
Osseointegration
biomechanics
Young Adult
03 medical and health sciences
Amputees
medicine
Humans
BIOCHEMICAL MARKERS
Device Removal
Aged
Transfemoral amputation
HIP
CLINICAL CONSEQUENCES
business.industry
Surgery
sense organs
business
bone mineral density
prosthetic interface mechanics
Biomarkers
030217 neurology & neurosurgery
SYSTEM
Zdroj: Hansen, R L, Langdahl, B L, Jørgensen, P H, Petersen, K K, Søballe, K & Stilling, M 2019, ' Changes in periprosthetic bone mineral density and bone turnover markers after osseointegrated implant surgery: A cohort study of 20 transfemoral amputees with 30-month follow-up ', Prosthetics and Orthotics International, vol. 43, no. 5, pp. 508-518 . https://doi.org/10.1177/0309364619866599
Popis: Background: The osseointegrated implant system is a treatment option for people with transfemoral amputation, but implant removal is not uncommon. The association between bone mineral density changes or bone turnover markers and the need for implant removal has not previously been investigated. Objectives: The aim was to evaluate changes in bone mineral density and bone turnover markers in people with transfemoral amputations treated with osseointegrated implants. Study design: This is a prospective cohort study. Methods: Nineteen patients were followed up for 30 months or until implant removal. Bone mineral density was measured in the lumbar spine, proximal femur and seven periprosthetic regions. 25-hydroxyvitamin (D2 + D3), parathyroid hormone, N-terminal propeptide of type-I procollagen, C-telopeptide of type-I collagen, bone-specific alkaline phosphatase and osteocalcin were measured in blood samples. Results: Four fixtures and three abutments were removed. Patients with removed implants had a decreased bone mineral density in the seven periprosthetic regions between 27% (95% confidence interval = 6; 43) and 38% (95% confidence interval = 19; 52) at 30-month follow-up compared to baseline (p 0.08). C-telopeptide of type-I collagen was significantly different between the groups at 18- and 24-month follow-up (p 0.07). Conclusion: Implant removal was associated with loss of periprosthetic bone mineral density and increase in C-telopeptide of type-I collagen in the years following osseointegrated surgery.
Databáze: OpenAIRE
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