Changes in periprosthetic bone mineral density and bone turnover markers after osseointegrated implant surgery: A cohort study of 20 transfemoral amputees with 30-month follow-up
Autor: | Klaus Kjær Petersen, Peter Holmberg Jørgensen, Maiken Stilling, Rehne Lessmann Hansen, Bente L. Langdahl, Kjeld Søballe |
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Jazyk: | angličtina |
Rok vydání: | 2019 |
Předmět: |
Male
030506 rehabilitation bone turnover Periprosthetic AMPUTATION PROSTHESES Health Professions (miscellaneous) Bone remodeling Absorptiometry Photon 0302 clinical medicine Bone Density QUALITY-OF-LIFE FIXATION Femur Prospective Studies skin and connective tissue diseases Bone mineral RISK Bone-Anchored Prosthesis Rehabilitation Treatment options Middle Aged Female Bone Remodeling 0305 other medical science Cohort study Month follow up Adult REHABILITATION medicine.medical_specialty Adolescent Artificial Limbs Osseointegration biomechanics Young Adult 03 medical and health sciences Amputees medicine Humans BIOCHEMICAL MARKERS Device Removal Aged Transfemoral amputation HIP CLINICAL CONSEQUENCES business.industry Surgery sense organs business bone mineral density prosthetic interface mechanics Biomarkers 030217 neurology & neurosurgery SYSTEM |
Zdroj: | Hansen, R L, Langdahl, B L, Jørgensen, P H, Petersen, K K, Søballe, K & Stilling, M 2019, ' Changes in periprosthetic bone mineral density and bone turnover markers after osseointegrated implant surgery: A cohort study of 20 transfemoral amputees with 30-month follow-up ', Prosthetics and Orthotics International, vol. 43, no. 5, pp. 508-518 . https://doi.org/10.1177/0309364619866599 |
Popis: | Background: The osseointegrated implant system is a treatment option for people with transfemoral amputation, but implant removal is not uncommon. The association between bone mineral density changes or bone turnover markers and the need for implant removal has not previously been investigated. Objectives: The aim was to evaluate changes in bone mineral density and bone turnover markers in people with transfemoral amputations treated with osseointegrated implants. Study design: This is a prospective cohort study. Methods: Nineteen patients were followed up for 30 months or until implant removal. Bone mineral density was measured in the lumbar spine, proximal femur and seven periprosthetic regions. 25-hydroxyvitamin (D2 + D3), parathyroid hormone, N-terminal propeptide of type-I procollagen, C-telopeptide of type-I collagen, bone-specific alkaline phosphatase and osteocalcin were measured in blood samples. Results: Four fixtures and three abutments were removed. Patients with removed implants had a decreased bone mineral density in the seven periprosthetic regions between 27% (95% confidence interval = 6; 43) and 38% (95% confidence interval = 19; 52) at 30-month follow-up compared to baseline (p 0.08). C-telopeptide of type-I collagen was significantly different between the groups at 18- and 24-month follow-up (p 0.07). Conclusion: Implant removal was associated with loss of periprosthetic bone mineral density and increase in C-telopeptide of type-I collagen in the years following osseointegrated surgery. |
Databáze: | OpenAIRE |
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