Mesenchymal Stem Cell–derived Nanovesicles as a Credible Agent for Therapy of Pulmonary Hypertension

Autor:	Li Hu, Jie Wang, Donghai Lin, Yueyao Shen, Huijie Huang, Yue Cao, Yan Li, Kai Li, Yanfang Yu, Youjia Yu, Chunyan Chu, Lianju Qin, Xiaojian Wang, Haifeng Zhang, David Fulton, Feng Chen
Rok vydání:	2022
Předmět:	Pulmonary and Respiratory Medicine Disease Models Animal Extracellular Vesicles MicroRNAs Monocrotaline Hypertension Pulmonary Clinical Biochemistry Animals Mesenchymal Stem Cells Cell Biology Molecular Biology Rats
Zdroj:	American Journal of Respiratory Cell and Molecular Biology. 67:61-75
ISSN:	1535-4989 1044-1549
DOI:	10.1165/rcmb.2021-0415oc
Popis:	Extracellular vesicles (EVs) derived from mesenchymal stem cells (MSCs) have been evaluated in many studies as promising therapeutic agents for pulmonary hypertension (PH). However, low yields and heterogeneity are major barriers in the translational utility of EVs for clinical studies. To address these limitations, we fabricated MSC-derived nanovesicles (MSC-NVs) by serial extrusion through filters, resulting in MSC-NVs with characteristics similar to conventional EVs but with much higher production yields. Herein, we examined the therapeutic efficacy of MSC-NVs in preclinical models of PH
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdfe56d270752d9f21c2f9ac343f3783 https://doi.org/10.1165/rcmb.2021-0415oc Zobrazit plný text záznamu