Inhibitory Control of Prefrontal Cortex by the Claustrum
| Autor: | Jesse Jackson, Boris V. Zemelman, Albert K. Lee, Denis Burdakov, Mahesh M. Karnani |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Male Prefrontal Cortex Mice Transgenic NPY PV Biology feed-forward inhibition neurogliaform cell Article Basal Ganglia 03 medical and health sciences Mice 0302 clinical medicine Organ Culture Techniques Cortex (anatomy) Inhibitory control Neural Pathways neocortex medicine Animals Rats Long-Evans prefrontal Prefrontal cortex microcircuit Neocortex General Neuroscience somatostatin interneuron Neural Inhibition Neuropeptide Y receptor Claustrum Rats VIP Mice Inbred C57BL 030104 developmental biology medicine.anatomical_structure nervous system claustrum Excitatory postsynaptic potential biology.protein Female Neuroscience 030217 neurology & neurosurgery Parvalbumin |
| Zdroj: | Neuron |
| ISSN: | 1097-4199 |
| Popis: | Summary The claustrum is a small subcortical nucleus that has extensive excitatory connections with many cortical areas. While the anatomical connectivity from the claustrum to the cortex has been studied intensively, the physiological effect and underlying circuit mechanisms of claustrocortical communication remain elusive. Here we show that the claustrum provides strong, widespread, and long-lasting feedforward inhibition of the prefrontal cortex (PFC) sufficient to silence ongoing neural activity. This claustrocortical feedforward inhibition was predominantly mediated by interneurons containing neuropeptide Y, and to a lesser extent those containing parvalbumin. Therefore, in contrast to other long-range excitatory inputs to the PFC, the claustrocortical pathway is designed to provide overall inhibition of cortical activity. This unique circuit organization allows the claustrum to rapidly and powerfully suppress cortical networks and suggests a distinct role for the claustrum in regulating cognitive processes in prefrontal circuits. Graphical Abstract Highlights • The claustrum strongly inhibits, rather than excites, prefrontal cortex • Prefrontal NPY and PV interneurons are activated by the claustrum • Claustrocortical feedforward inhibition is predominantly mediated by NPY neurons The claustrum provides a dense synaptic input to the cortex, but how claustrocortical projections modulate cortical activity is not known. Jackson et al. show that claustrocortical connections serve to inhibit cortical neural networks by activating specific subtypes of cortical interneurons. |
| Databáze: | OpenAIRE |
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