Ceftizoxime (FK 749), a new parenteral cephalosporin: in vitro and in vivo antibacterial activities
| Autor: | Sachiko Goto, Naohiko Okada, Minoru Nishida, Toshiaki Kamimura, Yoshimi Matsumoto, Y Mine, Shogo Kuwahara |
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| Rok vydání: | 1979 |
| Předmět: |
Male
Cefotaxime medicine.drug_class Cephalosporin Microbial Sensitivity Tests Biology Cefmetazole Microbiology Cefotiam Mice Ceftizoxime medicine Animals Pharmacology (medical) Cefamandole Pharmacology Bacteria Drug Resistance Microbial Bacterial Infections Cephalosporins Infectious Diseases Ticarcillin Cefuroxime Injections Intraperitoneal Research Article medicine.drug |
| Zdroj: | Antimicrobial Agents and Chemotherapy. 16:540-548 |
| ISSN: | 1098-6596 0066-4804 |
| DOI: | 10.1128/aac.16.5.540 |
| Popis: | FK 749 is a new parenteral cephalosporin derivative which is more active against various gram-negative bacilli, including the opportunistic pathogens such as Enterobacter, Citrobacter species, and Serratia marcescens, than cephalosporins and cephamycins such as cefotiam, cefamandole, cefuroxime, cefotaxime, and cefmetazole. FK 749 was especially active against gram-negative organisms resistant to these related antibiotics. FK 749 was more potent in bactericidal activity than the other antibiotics, and the activity was clearly enhanced in the presence of 90% defibrinated rabbit blood. The therapeutic effect of subcutaneously injected FK 749 in mice infected with various gram-negative bacilli was far superior to that of cefotiam, cefamandole, cefuroxime, and cefmetazole and was almost the same as that of cefmetazole in mice infected with Staphylococcus aureus and that of ticarcillin in mice infected with Pseudomonas aeruginosa. FK 749 has, in general, nearly the same in vitro and in vivo antibacterial activities as cefotaxime. The former had more potent bactericidal activity in the presence of the blood than the latter and showed more excellent therapeutic effect than cefotaxime against infections caused by large inoculum sizes. |
| Databáze: | OpenAIRE |
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