Ex Vivo Lung Perfusion: A Platform for Donor Lung Assessment, Treatment and Recovery
| Autor: | Andrew J. Fisher, Luke Milross, Chelsea Griffiths |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Lung RD1-811 business.industry medicine.medical_treatment Ex vivo lung perfusion Primary Graft Dysfunction Cold storage ex vivo lung perfusion respiratory system respiratory tract diseases Donor lungs Transplantation medicine.anatomical_structure Lung disease Internal medicine lung transplantation medicine Cardiology normothermic machine perfusion Lung transplantation Surgery business |
| Zdroj: | Transplantology, Vol 2, Iss 37, Pp 387-395 (2021) |
| ISSN: | 2673-3943 |
| DOI: | 10.3390/transplantology2040037 |
| Popis: | Lung transplantation offers a lifesaving therapy for patients with end-stage lung disease but its availability is presently limited by low organ utilization rates with donor lungs frequently excluded due to unsuitability at assessment. When transplantation does occur, recipients are then vulnerable to primary graft dysfunction (PGD), multitudinous short-term complications, and chronic lung allograft dysfunction. The decision whether to use donor lungs is made rapidly and subjectively with limited information and means many lungs that might have been suitable are lost to the transplant pathway. Compared to static cold storage (SCS), ex vivo lung perfusion (EVLP) offers clinicians unrivalled opportunity for rigorous objective assessment of donor lungs in conditions replicating normal physiology, thus allowing for better informed decision-making in suitability assessments. EVLP additionally offers a platform for the delivery of intravascular or intrabronchial therapies to metabolically active tissue aiming to treat existing lung injuries. In the future, EVLP may be employed to provide a pre-transplant environment optimized to prevent negative outcomes such as primary graft dysfunction (PGD) or rejection post-transplant. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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