Management of Early-Stage Hodgkin's Lymphoma
| Autor: | Alfred Rademaker, William N. Brand, Michael A. LaCombe, Leo I. Gordon, Laura A. Colangelo, Harold H. Kim, John M. Merrill, Bharat B. Mittal |
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| Rok vydání: | 1996 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Adolescent medicine.medical_treatment Laparotomy medicine Humans Combined Modality Therapy Stage (cooking) Aged Retrospective Studies Aged 80 and over Salvage Therapy Chemotherapy business.industry Middle Aged Prognosis Hodgkin's lymphoma medicine.disease Hodgkin Disease Surgery Lymphoma Survival Rate Radiation therapy Oncology Female business Complication |
| Zdroj: | American Journal of Clinical Oncology. 19:235-240 |
| ISSN: | 0277-3732 |
| Popis: | Early-stage Hodgkin's lymphoma patients treated with radiotherapy alone or combined modality therapy were retrospectively analyzed for survival, patterns of failure, salvage, and toxicity. Of 75 evaluable patients, 47 were given radiotherapy alone and 28 were given combination radiotherapy and chemotherapy. Of the patients studied, 26 were clinical stage I and 49 were clinical stage II, with nine patients upstaged at laparotomy. Minimum follow-up was 2 years, with a median of 81 months. Complete response rate was 95%. Relapse-free survival and overall survival were 89% and 96%, respectively, at 2 years ; 78% and 86% at 5 years ; and 76% and 82% at 10 years. Of 16 patients who relapsed (21%), 13/47 patients were treated with radiotherapy and 3/28 were treated with combined modality therapy. Salvage rates were higher in those treated with radiotherapy alone. There were 13 deaths : six from disease, two from treatment-related complications, and five from second primary malignancies. There was a higher incidence of second malignancies and deaths due to complication in patients treated with combined modality therapy. Radiotherapy alone or with chemotherapy is an effective modality in the treatment of Hodgkin's lymphoma. Treatment should be selected properly to optimize results and decrease complications. |
| Databáze: | OpenAIRE |
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