Erythropoietin, progenitors, and repair
| Autor: | A.J. van Zonneveld, Ton J. Rabelink, Ingeborg M. Bajema, Z. Aydin, J. Duijs |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Kidney
Endothelium Cell Survival Stem Cells Renal function Endothelial Cells Biology Endothelial progenitor cell Erythropoietin receptor medicine.anatomical_structure Nephrology Erythropoietin hemic and lymphatic diseases Immunology medicine Cancer research Receptors Erythropoietin Animals Humans Regeneration Progenitor cell Function (biology) medicine.drug |
| Zdroj: | ResearcherID |
| ISSN: | 0098-6577 |
| Popis: | The erythropoietin–erythropoietin-receptor (EPO–EPO-R) system has recently been identified as an important cellular survival pathway. Its presence has also been demonstrated in the kidney and identified as a therapeutic target to prevent loss of renal function. Part of the protective effects may be related to the action of erythropoietin on endothelial function and expansion of endothelial progenitor cells. This paper reviews current evidence for involvement of these mechanisms in EPO-mediated renoprotection. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|