Combined glutathione S-transferase T1 and M1 positive genotypes afford protection against Type 2 diabetes in Japanese
| Autor: | Kazuko Nakagawa, Toru Marubayashi, Masaharu Hori, Kentaro Oniki, Shuji Goto, Kentaro Ueda, Shuichi Mihara |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Adult
Male medicine.medical_specialty Genotype Type 2 diabetes Biology medicine.disease_cause chemistry.chemical_compound Asian People Japan Diabetes mellitus Internal medicine Genetics medicine Humans Aged Glutathione Transferase Pharmacology Incidence Incidence (epidemiology) Odds ratio Glutathione Middle Aged medicine.disease Cross-Sectional Studies Endocrinology Glutathione S-transferase Diabetes Mellitus Type 2 chemistry Cardiovascular Diseases Case-Control Studies biology.protein Molecular Medicine Female Diabetic Angiopathies Oxidative stress |
| Zdroj: | Pharmacogenomics. 8:1307-1314 |
| ISSN: | 1744-8042 1462-2416 |
| Popis: | Introduction: Diabetes mellitus is associated with an increased production of reactive oxygen species and a reduction in antioxidant defenses. The aim of this study is to determine the association between the incidence of Type 2 diabetes and gene polymorphisms of glutathione S-transferase (GST), which modulates oxidative stress. Materials & Methods: The associations between the incidence of Type 2 diabetes and the GSTT1 and GSTM1 genotypes were analyzed in 469 Japanese participants in a health-screening program. Results: The clinical characteristics and smoking status were obtained from the health screening record. The incidence of diabetes was 1.5-fold higher in the GSTT1 and GSTM1 null (-) genotype than the GSTT1 and GSTM1 present (+) genotype, respectively. Although the effect of each null genotype was not significant, the combined GSTT1+/GSTM1+ genotypes conferred a significant reduction in risk of diabetes in comparison with the other combinations of genotypes (adjusted odds ratio [OR]: 0.30; 95% confidence interval [CI]: 0.12–0.71). In stratified analyses by smoking status, the incidence of diabetes was significantly higher in never-smokers with the GSTT1- genotype than those with the GSTT1+ genotype (OR: 2.85; 95% CI: 1.17–6.94) and increased significantly in current smokers (OR: 5.91; 95% CI: 1.96–17.88). The effect of the GSTM1- genotype was significant only in current smokers. Conclusion: This study demonstrated that the GSTT1- and GSTT1-/GSTM1- genotypes are independent risk factors for development of Type 2 diabetes regardless of the smoking status of the patient, and that these genotypes and current smoking were interactively associated with the incidence of Type 2 diabetes. |
| Databáze: | OpenAIRE |
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