Emerging Roles of SPINK1 in Cancer
| Autor: | Ulf-Håkan Stenman, Hannu Koistinen, Kati Räsänen, Outi Itkonen |
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| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Trypsin inhibitor Clinical Biochemistry Breast Neoplasms Inhibitor of apoptosis 03 medical and health sciences 0302 clinical medicine PstI Neoplasms Internal medicine Pancreatic cancer medicine Humans Pancreatic Secretory Trypsin Inhibitor Tumor marker Ovarian Neoplasms biology Biochemistry (medical) Prostatic Neoplasms Cancer medicine.disease Protease inhibitor (biology) 3. Good health Pancreatic Neoplasms 030104 developmental biology Endocrinology Trypsin Inhibitor Kazal Pancreatic 030220 oncology & carcinogenesis biology.protein Cancer research Female Carrier Proteins medicine.drug |
| Zdroj: | Clinical Chemistry. 62:449-457 |
| ISSN: | 1530-8561 0009-9147 |
| Popis: | BACKGROUNDTumor-associated trypsin inhibitor (TATI) was originally isolated from the urine of a patient with ovarian cancer. It was later shown to be produced by many other tumors and several normal tissues. It had earlier been isolated from the pancreas and was hence called pancreatic secretory trypsin inhibitor (PSTI). It belongs to a family of protease inhibitors presently called serine peptidase inhibitor Kazal type (SPINK). In the SPINK family TATI/PSTI is SPINK1, which is the name used in this review.CONTENTIn addition to being a protease inhibitor, SPINK1 also acts as an acute-phase reactant and a growth factor. Furthermore, it has been shown to modulate apoptosis. Overexpression of SPINK1 predicts an unfavorable outcome in several cancers and determination of SPINK1 in serum can be used to identify patients at increased risk of aggressive disease. Thus serum SPINK1 can be used as a prognostic tumor marker. Because SPINK1 acts as a growth factor and an inhibitor of apoptosis in some cancers, it has also been suggested that it can be a therapeutic target in cancer. However, because SPINK1 is the major physiological inhibitor of trypsin, inhibition of SPINK1 may increase the risk of pancreatitis.SUMMARYTaking into account the many functions of SPINK1, assessing the role of SPINK1 in cancer has several potentially important clinical applications ranging from a biomarker to a potential new target for cancer therapy. |
| Databáze: | OpenAIRE |
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