Manganese: elemental defence for a life with oxygen
| Autor: | Michaeil Karavolos, Stephen J. Wharton, Simon J. Foster, Malcolm J. Horsburgh |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Microbiology (medical)
Defence mechanisms Microbial metabolism medicine.disease_cause Microbiology Models Biological Antioxidants Superoxide dismutase chemistry.chemical_compound Virology Detoxification medicine chemistry.chemical_classification Reactive oxygen species Manganese biology Bacteria Virulence Superoxide Biological Transport Peroxides Oxygen Infectious Diseases Biochemistry chemistry Catalase biology.protein Energy Metabolism Reactive Oxygen Species Oxidative stress |
| Zdroj: | Trends in microbiology. 10(11) |
| ISSN: | 0966-842X |
| Popis: | The presence of enzymes such as catalase, peroxidase and superoxide dismutase (SOD) obviates the problems associated with life in an aerobic environment by eliminating the harmful reactive oxygen species (ROS) that arise from respiration. Enzymic detoxification of ROS might not, however, be the only mechanism at work in bacteria. The accumulation of manganese (Mn), an abundant element in many environments, via several, recently identified transporters is thought to form the basis for an alternative, catalytic detoxification of ROS. An increasing body of evidence from work on the genetics and biochemistry of Mn accumulation and its cellular roles reveals that this overlooked defence mechanism is likely to be widespread among bacteria and might also contribute to virulence. |
| Databáze: | OpenAIRE |
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